Random Network Models to Predict the Long-Term Impact of HPV Vaccination on Genital Warts
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FISABIO-Public Health, 46020 Valencia, Spain
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Instituto Universitario de Matemática Multidisciplinar, 8G building, 2nd Floor, Camino de Vera, Universitat Politècnica de Valéncia, 46022 Valencia, Spain
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Departamento de Ciencias de la Computación, Arquitectura de Computadores, Lenguajes y Sistemas Informáticos, Estadística e Investigación Operativa, Universidad Rey Juan Carlos, Móstoles, 28933 Madrid, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Curt Hagerdorn
Viruses 2017, 9(10), 300; https://doi.org/10.3390/v9100300
Received: 27 July 2017 / Revised: 11 October 2017 / Accepted: 13 October 2017 / Published: 16 October 2017
(This article belongs to the Section Antivirals & Vaccines)
The Human papillomaviruses (HPV) vaccine induces a herd immunity effect in genital warts when a large number of the population is vaccinated. This aspect should be taken into account when devising new vaccine strategies, like vaccination at older ages or male vaccination. Therefore, it is important to develop mathematical models with good predictive capacities. We devised a sexual contact network that was calibrated to simulate the Spanish epidemiology of different HPV genotypes. Through this model, we simulated the scenario that occurred in Australia in 2007, where 12–13 year-old girls were vaccinated with a three-dose schedule of a vaccine containing genotypes 6 and 11, which protect against genital warts, and also a catch-up program in women up to 26 years of age. Vaccine coverage were in girls with three doses and with coverage rates decreasing with age until for 20–26 year-olds. A fast reduction in the genital warts diagnoses occurred in the model in the first years after the start of the program, similar to what was described in the literature.
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Keywords:
human papillomavirus; network model; vaccination strategies
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MDPI and ACS Style
Díez-Domingo, J.; Sánchez-Alonso, V.; Villanueva, R.-J.; Acedo, L.; Moraño, J.-A.; Villanueva-Oller, J. Random Network Models to Predict the Long-Term Impact of HPV Vaccination on Genital Warts. Viruses 2017, 9, 300.
AMA Style
Díez-Domingo J, Sánchez-Alonso V, Villanueva R-J, Acedo L, Moraño J-A, Villanueva-Oller J. Random Network Models to Predict the Long-Term Impact of HPV Vaccination on Genital Warts. Viruses. 2017; 9(10):300.
Chicago/Turabian StyleDíez-Domingo, Javier; Sánchez-Alonso, Víctor; Villanueva, Rafael-J.; Acedo, Luis; Moraño, José-Antonio; Villanueva-Oller, Javier. 2017. "Random Network Models to Predict the Long-Term Impact of HPV Vaccination on Genital Warts" Viruses 9, no. 10: 300.
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