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Viruses 2016, 8(9), 248;

The Life-Cycle of the HIV-1 Gag–RNA Complex

Architecture et Réactivité de l’ARN, Université de Strasbourg, IBMC, CNRS, 15 rue René Descartes, 67084 Strasbourg, France
Authors to whom correspondence should be addressed.
Academic Editor: Eric O. Freed
Received: 15 July 2016 / Revised: 30 August 2016 / Accepted: 2 September 2016 / Published: 10 September 2016
(This article belongs to the Special Issue RNA Packaging)
Full-Text   |   PDF [961 KB, uploaded 10 September 2016]   |  


Human immunodeficiency virus type 1 (HIV-1) replication is a highly regulated process requiring the recruitment of viral and cellular components to the plasma membrane for assembly into infectious particles. This review highlights the recent process of understanding the selection of the genomic RNA (gRNA) by the viral Pr55Gag precursor polyprotein, and the processes leading to its incorporation into viral particles. View Full-Text
Keywords: HIV-1; packaging; Gag; genomic RNA; assembly HIV-1; packaging; Gag; genomic RNA; assembly

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Mailler, E.; Bernacchi, S.; Marquet, R.; Paillart, J.-C.; Vivet-Boudou, V.; Smyth, R.P. The Life-Cycle of the HIV-1 Gag–RNA Complex. Viruses 2016, 8, 248.

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