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Regulation of Stress Responses and Translational Control by Coronavirus

School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore
Department of Avian Diseases, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Ziyue Road 518, Shanghai 200241, China
Authors to whom correspondence should be addressed.
Academic Editor: Craig McCormick
Viruses 2016, 8(7), 184;
Received: 3 March 2016 / Revised: 21 June 2016 / Accepted: 28 June 2016 / Published: 4 July 2016
(This article belongs to the Special Issue Viral Subversion of Stress Responses and Translational Control)
PDF [850 KB, uploaded 5 July 2016]


Similar to other viruses, coronavirus infection triggers cellular stress responses in infected host cells. The close association of coronavirus replication with the endoplasmic reticulum (ER) results in the ER stress responses, which impose a challenge to the viruses. Viruses, in turn, have come up with various mechanisms to block or subvert these responses. One of the ER stress responses is inhibition of the global protein synthesis to reduce the amount of unfolded proteins inside the ER lumen. Viruses have evolved the capacity to overcome the protein translation shutoff to ensure viral protein production. Here, we review the strategies exploited by coronavirus to modulate cellular stress response pathways. The involvement of coronavirus-induced stress responses and translational control in viral pathogenesis will also be briefly discussed. View Full-Text
Keywords: coronavirus; ER stress; unfolded protein response; p38; JNK; eIF2α; PKR; PERK; GADD34/PP1; nsp1; translational control coronavirus; ER stress; unfolded protein response; p38; JNK; eIF2α; PKR; PERK; GADD34/PP1; nsp1; translational control

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Fung, T.S.; Liao, Y.; Liu, D.X. Regulation of Stress Responses and Translational Control by Coronavirus. Viruses 2016, 8, 184.

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