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Early Bunyavirus-Host Cell Interactions

Molecular Virology Laboratory, Fundación Ciencia & Vida, Av. Zañartu 1482, 7780272 Santiago, Chile
CellNetworks—Cluster of Excellence and Department of Infectious Diseases, Virology, University Hospital Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Eric O. Freed
Viruses 2016, 8(5), 143;
Received: 30 March 2016 / Accepted: 15 May 2016 / Published: 24 May 2016
(This article belongs to the Special Issue Recent Progress in Bunyavirus Research)
PDF [2352 KB, uploaded 24 May 2016]


The Bunyaviridae is the largest family of RNA viruses, with over 350 members worldwide. Several of these viruses cause severe diseases in livestock and humans. With an increasing number and frequency of outbreaks, bunyaviruses represent a growing threat to public health and agricultural productivity globally. Yet, the receptors, cellular factors and endocytic pathways used by these emerging pathogens to infect cells remain largely uncharacterized. The focus of this review is on the early steps of bunyavirus infection, from virus binding to penetration from endosomes. We address current knowledge and advances for members from each genus in the Bunyaviridae family regarding virus receptors, uptake, intracellular trafficking and fusion. View Full-Text
Keywords: bunyavirus; cell entry; endocytosis; hantavirus; RNA virus; tospovirus; virus membrane fusion; virus receptor bunyavirus; cell entry; endocytosis; hantavirus; RNA virus; tospovirus; virus membrane fusion; virus receptor

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Albornoz, A.; Hoffmann, A.B.; Lozach, P.-Y.; Tischler, N.D. Early Bunyavirus-Host Cell Interactions. Viruses 2016, 8, 143.

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