Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence
AbstractHuman T-cell leukemia virus type 1 (HTLV-1) is a retrovirus that causes cancer (Adult T cell Leukemia, ATL) and a spectrum of inflammatory diseases (mainly HTLV-associated myelopathy—tropical spastic paraparesis, HAM/TSP). Since virions are particularly unstable, HTLV-1 transmission primarily occurs by transfer of a cell carrying an integrated provirus. After transcription, the viral genomic RNA undergoes reverse transcription and integration into the chromosomal DNA of a cell from the newly infected host. The virus then replicates by either one of two modes: (i) an infectious cycle by virus budding and infection of new targets and (ii) mitotic division of cells harboring an integrated provirus. HTLV-1 replication initiates a series of mechanisms in the host including antiviral immunity and checkpoint control of cell proliferation. HTLV-1 has elaborated strategies to counteract these defense mechanisms allowing continuous persistence in humans. View Full-Text
Share & Cite This Article
Carpentier, A.; Barez, P.-Y.; Hamaidia, M.; Gazon, H.; de Brogniez, A.; Perike, S.; Gillet, N.; Willems, L. Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence. Viruses 2015, 7, 3603-3624.
Carpentier A, Barez P-Y, Hamaidia M, Gazon H, de Brogniez A, Perike S, Gillet N, Willems L. Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence. Viruses. 2015; 7(7):3603-3624.Chicago/Turabian Style
Carpentier, Alexandre; Barez, Pierre-Yves; Hamaidia, Malik; Gazon, Hélène; de Brogniez, Alix; Perike, Srikanth; Gillet, Nicolas; Willems, Luc. 2015. "Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence." Viruses 7, no. 7: 3603-3624.