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Viruses 2015, 7(4), 1804-1822;

A Suggested New Bacteriophage Genus, “Kp34likevirus”, within the Autographivirinae Subfamily of Podoviridae

Department of Molecular Biosciences, the Wenner-Gren Institute, Stockholm University, Stockholm 106 91, Sweden
Institute of Genetics and Microbiology, University of Wroclaw, Wroclaw 51-148, Poland
Department of Microbiology, Public Health Agency of Sweden, Solna 171 82, Sweden
Department of Microbiology, National Taiwan University, College of Medicine, Taipei 10051, Taiwan
Departments of Food Science, Molecular & Cellular Biology, and Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada
Author to whom correspondence should be addressed.
Academic Editors: Abram Aertsen and Rob Lavigne
Received: 11 February 2015 / Revised: 22 March 2015 / Accepted: 27 March 2015 / Published: 7 April 2015
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Klebsiella pneumoniae phages vB_KpnP_SU503 (SU503) and vB_KpnP_SU552A (SU552A) are virulent viruses belonging to the Autographivirinae subfamily of Podoviridae that infect and kill multi-resistant K. pneumoniae isolates. Phages SU503 and SU552A show high pairwise nucleotide identity to Klebsiella phages KP34 (NC_013649), F19 (NC_023567) and NTUH-K2044-K1-1 (NC_025418). Bioinformatic analysis of these phage genomes show high conservation of gene arrangement and gene content, conserved catalytically active residues of their RNA polymerase, a common and specific lysis cassette, and form a joint cluster in phylogenetic analysis of their conserved genes. Also, we have performed biological characterization of the burst size, latent period, host specificity (together with KP34 and NTUH-K2044-K1-1), morphology, and structural genes as well as sensitivity testing to various conditions. Based on the analyses of these phages, the creation of a new phage genus is suggested within the Autographivirinae, called “Kp34likevirus” after their type phage, KP34. This genus should encompass the recently genome sequenced Klebsiella phages KP34, SU503, SU552A, F19 and NTUH-K2044-K1-1. View Full-Text
Keywords: “Kp34likevirus”; phikmvlikevirus; Autographivirinae; Klebsiella pneumoniae; bacteriophage; phage; Podoviridae “Kp34likevirus”; phikmvlikevirus; Autographivirinae; Klebsiella pneumoniae; bacteriophage; phage; Podoviridae

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Eriksson, H.; Maciejewska, B.; Latka, A.; Majkowska-Skrobek, G.; Hellstrand, M.; Melefors, Ö.; Wang, J.-T.; Kropinski, A.M.; Drulis-Kawa, Z.; Nilsson, A.S. A Suggested New Bacteriophage Genus, “Kp34likevirus”, within the Autographivirinae Subfamily of Podoviridae. Viruses 2015, 7, 1804-1822.

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