Next Article in Journal / Special Issue
Efficient Strategy to Generate a Vectored Duck Enteritis Virus Delivering Envelope of Duck Tembusu Virus
Previous Article in Journal / Special Issue
Alphavirus-Based Vaccines
Article Menu

Export Article

Open AccessReview
Viruses 2014, 6(6), 2416-2427;

Vaccination against δ-Retroviruses: The Bovine Leukemia Virus Paradigm

Instituto de Virología, Centro de Investigaciones en Ciencias Veterinarias y Agronómicas, INTA, C.C. 1712, Castelar, Argentina
Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (Gembloux Agro-Bio Tech), University of Liège (ULg), 4000 Liège, Belgium
These authors contributed equally to this work.
These authors designed and coordinated this study equally.
Author to whom correspondence should be addressed.
Received: 30 April 2014 / Revised: 10 June 2014 / Accepted: 11 June 2014 / Published: 20 June 2014
(This article belongs to the Special Issue Virus-based Vaccines)
Full-Text   |   PDF [658 KB, uploaded 12 May 2015]   |  


Bovine leukemia virus (BLV) and human T-lymphotropic virus type 1 (HTLV-1) are closely related d-retroviruses that induce hematological diseases. HTLV-1 infects about 15 million people worldwide, mainly in subtropical areas. HTLV-1 induces a wide spectrum of diseases (e.g., HTLV-associated myelopathy/tropical spastic paraparesis) and leukemia/lymphoma (adult T-cell leukemia). Bovine leukemia virus is a major pathogen of cattle, causing important economic losses due to a reduction in production, export limitations and lymphoma-associated death. In the absence of satisfactory treatment for these diseases and besides the prevention of transmission, the best option to reduce the prevalence of d-retroviruses is vaccination. Here, we provide an overview of the different vaccination strategies in the BLV model and outline key parameters required for vaccine efficacy. View Full-Text
Keywords: BLV; neutralizing antibody; vaccine; mimotope; HTLV-1; attenuated virus BLV; neutralizing antibody; vaccine; mimotope; HTLV-1; attenuated virus

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Gutiérrez, G.; Rodríguez, S.M.; de Brogniez, A.; Gillet, N.; Golime, R.; Burny, A.; Jaworski, J.-P.; Alvarez, I.; Vagnoni, L.; Trono, K.; Willems, L. Vaccination against δ-Retroviruses: The Bovine Leukemia Virus Paradigm. Viruses 2014, 6, 2416-2427.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top