Viruses 2014, 6(3), 1015-1036; https://doi.org/10.3390/v6031015
B Cell Response and Mechanisms of Antibody Protection to West Nile Virus
1
Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
2
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
*
Author to whom correspondence should be addressed.
Received: 17 December 2013 / Revised: 7 February 2014 / Accepted: 8 February 2014 / Published: 3 March 2014
(This article belongs to the Special Issue West Nile Virus)
Abstract
West Nile virus (WNV) has become the principal cause of viral encephalitis in North America since its introduction in New York in 1999. This emerging virus is transmitted to humans via the bite of an infected mosquito. While there have been several candidates in clinical trials, there are no approved vaccines or WNV-specific therapies for the treatment of WNV disease in humans. From studies with small animal models and convalescent human patients, a great deal has been learned concerning the immune response to infection with WNV. Here, we provide an overview of a subset of that information regarding the humoral and antibody response generated during WNV infection. View Full-TextKeywords:
West Nile virus; flavivirus; humoral immunity; neutralizing antibody; epitopes; therapeutics
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MDPI and ACS Style
Austin, S.K.; Dowd, K.A. B Cell Response and Mechanisms of Antibody Protection to West Nile Virus. Viruses 2014, 6, 1015-1036.