Identification of Cellular Proteins that Interact with Human Cytomegalovirus Immediate-Early Protein 1 by Protein Array Assay
Abstract
:1. Introduction
2. Results
GenBank entry# | Name of the protein | Function | Ref. |
---|---|---|---|
AF217982 | CDK5 regulatory subunit associated protein | Tumorigenesis and metastasis | [35] |
D84294 | TPRDI (tetratricopeptide repeat) | Down syndrome | [36] |
BC069268 | Golgi autoantigen, golgin subfamily a | Tentacular matrix | [37] |
NM_007144 | Polycomb group ring Finger 2 (PCGF2) | Embryogenesis and tumorigenesis | [38] |
NM_005676 | RNA binding motif protein 10 (RBM10) | RNA-related apoptosis | [39] |
Z11584 | NuMA protein | Spindle orientation | [40] |
BC022880 | Breast carcinoma amplified sequence 2 | Negative regulator of p53 | [41] |
BC057387 | LSM14B, SCD6 homolog B | Regulation of translation | [42] |
BG354577 | CDCA4 Cell division cycle associated gene 4 | Transcription regulation | [43] |
NM_001789 | Cell division cycle 25 homolog A (CDC25A) | Cell cycle regulation | [44] |
NM_003026 | SH3-domain GRB2-like 2 (SH3GL2) | Tumorigenesis | [45] |
NM_203505 | GTPase activating protein binding protein 2 | Stress granule formation | [46] |
XM_001128623 | Transcriptional regulator ATRX | Transcriptional repression | [47] |
NM_153273 | Inositol hexaphosphate kinase 1 (IHPK1) | Type 2 diabetes | [48] |
NM_032019 | Histone deacetylase 10 (HDAC10) | Cancer metastasis | [49] |
NM_001040653 | ZXD family zinc finger C (ZXDC) | MHC gene transcription | [50] |
NM_138383 | Actin-bundling protein with BAIAP2 homology (ABBA-1) | unknown | [51] |
NM_001082486 | Adrenocortical dysplasia homolog (mouse) (ACD), transcript variant 1 | Tumorigenesis | [52] |
AK122898 | ADP-ribosylation factor binding protein GGA1 | Trans-olgi network | [53] |
AB208813 | RNA binding motif protein 5 | Gene splicing factor | [39] |
NM_170677 | Meis homeobox 2 (MEIS2) | Unknown | [54] |
NM_000038 | Adenomatosis polyposis coli (APC) | Tumor supresor | [55] |
NM_003660 | Protein tyrosine phosphatase, receptor type f polypeptide (PTPRF), interacting protein (liprin), alpha 3 (PPFIA3) | Unknown | [56] |
NM_012398 | Phosphatidylinositol-4-phosphate 5-kinase, type I, gamma (PIP5K1C) | Lethal contractural syndrome | [57] |
NM_003861 | WD repeat domain 22 (WDR22) | Unknown | N/A |
NM_017453 | Staufen, RNA binding protein | mRNA traffic | [58] |
BC017222 | Sequestosome 1 | Signal transduction | [59] |
NM_152586 | Ubiquitin specific peptidase 54 (USP54) | Unknown | [60] |
NM_014868 | Ring finger protein 10 (RNF10) | Type 2 diabetes | [61] |
BC041897 | SplA/ryanodine receptor domain and SOCS box containing 3 | Inflammation | [62] |
AB209534 | Tumor rejection antigen (gp96) 1 | Unknown | N/A |
NM_001080424 | Jumonji domain containing 3 (JMJD3) | Histone demethylation | [63] |
NM_006312 | Nuclear receptor co-repressor 2 (NCOR2) | Gene suppressor | [64] |
AK124656 | Gamma enolase (EC 4.2.1.11) | Neural tissue development | [65] |
AK123065 | Sperm acrosomal protein | Motility of the spermatozoon | [66] |
NM_001098800 | Melanoma antigen family D 4 (MAGED4) | Renal cell carcinoma | [67] |
NM_021098 | Calcium channel, voltage-dependent, T type, alpha 1H subunit (CACNA1H) | T-type Ca(2+) channel activity | [68] |
NM_001417 | Eukaryotic translation initiation factor 4B (EIF4B) | Translation control | [69] |
NM_002973 | Ataxin 2 (ATXN2) | Spinocerebellar ataxia type 2 | [70] |
BC070086 | Splicing factor, arginine/serine-rich 2 | Gene splicing | [18] |
NM_001675 | Activating transcription factor 4 (ATF4) | Gene transcription | [71] |
AB209149 | Phenol-sulfating phenol sulfotransferase 1 | Transfer of a sulfonate moiety | [72] |
AY509035 | Roundabout-like protein 3 (ROBO3) | Horizontal gaze palsy | [73] |
NM_014751 | Metastasis suppressor 1 (MTSS1) | Metastasis | [74] |
AY335491 | GON4L isoform C (GON4L) | Hematopoiesis | [75] |
NM_014739 | BCL2-associated transcription factor 1 | Transcriptional repression | [76] |
AB067518 | KIAA1931 protein | Unknown | N/A |
NM_003200 | Transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) (TCF3) | Transcription regulation | [77] |
AB209197 | Protein phosphatase 1 (PP1) | Multiple functions | [78] |
NM_020226 | PR domain containing 8 (PRDM8) | Gene repressor | [79] |
XM_166659 | OTU domain containing 1 (OTUD1) | Unknown | N/A |
NM_001098208 | Heterogeneous nuclear ribonucleoprotein F (HNRPF) | Gene splicing | [80] |
AB209441 | Fibroblast growth factor receptor 3 isoform 1 precursor | Development | [81] |
NM_152643 | Kinase non-catalytic C-lobe domain (KIND) containing 1 (KNDC1) | Unknown | N/A |
NM_001982 | V-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (ERBB3) | Cell proliferation or differentiation | [82] |
NM_015695 | Bromodomain and PHD finger containing, 3 (BRPF3) | Fetal liver erythropoiesis | [83] |
NM_015906 | Tripartite motif-containing 33 (TRIM33) | Tumor suppressors | [84] |
NM_032127 | Chromosome 11 open reading frame 56 (C11orf56) | FTS and Hook-interacting protein | [85] |
NM_002904 | RD RNA binding protein (RDBP) | Repress RNA polymerase II | N/A |
NM_012272 | PRP40 pre-mRNA processing factor 40 B (PRPF40B) | Gene splicing | [86] |
NM_020967 | Nuclear receptor coactivator 5 (NCOA5) | Gene regulator | [87] |
NM_001080495 | KIAA1856 protein (KIAA1856) | Unknown | N/A |
NM_022748 | Tensin 3 (TNS3) | Signal transduction | [88] |
BC063642 | Phosphodiesterase 4D interacting protein (myomegalin) | Control microtubules | [89] |
AB209493 | Death-associated protein 6 (DAXX) | Development and Cancer | [90] |
NM_003482 | Myeloid/lymphoid or mixed-lineage leukemia 2 (MLL2) | Lymphomagenesis | [91] |
NM_033396 | Tankyrase 1 binding protein 1, (TNKS1BP1) | Unknown | [92] |
AY729650 | Intersex-like protein | Unknown | [93] |
BC110647 | Immediate-early response 2 | Unknown | N/A |
AB014581 | KIAA0681 protein | Unknown | N/A |
NM_004235 | Kruppel-like factor 4 (gut) (KLF4) | Transactivation and growth suppression | [94] |
AB051455 | KIAA1668 protein | Unknown | N/A |
AF045458 | Serine/threonine kinase ULK1 (ULK1) | Autophagy activation | [95] |
NM_001003694 | Bromodomain and PHD finger containing, 1 (BRPF1) | Unknown | N/A |
NM_003626 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 (PPFIA1) | Unknown | N/A |
NM_006291 | tumor necrosis factor, alpha-induced protein 2 (TNFAIP2) | Unknown | N/A |
AB209643 | smoothelin isoform b | Unknown | N/A |
NM_002857 | peroxisomal biogenesis factor 19 (PEX19) | Peroxisomal assembly | [96] |
AB061669 | receptor for advanced glycation end-products | Signaling and inflammation | [97] |
NM_014678 | SAPS domain family, member 2 (SAPS2) | Unknown | N/A |
NM_006887 | zinc finger protein 36, C3H type-like 2 (ZFP36L2) | Unknown | N/A |
AB208876 | axin 1 isoform | Wnt signaling pathway | [98] |
NM_004530 | matrix metallopeptidase 2 (MMP2) | Metastasis and inflammation | [99] |
3. Discussion
4. Experimental
4.1. Tissue Culture and Viruses
4.2. Antibodies
4.3. Preparation of Nuclear Extracts
4.4. Coimmunoprecipitation
4.5. Immunoblot Analysis
5. Conclusions
Acknowledgements
Conflicts of Interest
References and Notes
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Martínez, F.P.; Tang, Q. Identification of Cellular Proteins that Interact with Human Cytomegalovirus Immediate-Early Protein 1 by Protein Array Assay. Viruses 2014, 6, 89-105. https://doi.org/10.3390/v6010089
Martínez FP, Tang Q. Identification of Cellular Proteins that Interact with Human Cytomegalovirus Immediate-Early Protein 1 by Protein Array Assay. Viruses. 2014; 6(1):89-105. https://doi.org/10.3390/v6010089
Chicago/Turabian StyleMartínez, Francisco Puerta, and Qiyi Tang. 2014. "Identification of Cellular Proteins that Interact with Human Cytomegalovirus Immediate-Early Protein 1 by Protein Array Assay" Viruses 6, no. 1: 89-105. https://doi.org/10.3390/v6010089