Stem-Cell-Based Gene Therapy for HIV Infection
Department of Medicine, Division of Hematology and Oncology, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA
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Viruses 2014, 6(1), 1-12; https://doi.org/10.3390/v6010001
Received: 1 November 2013 / Revised: 16 December 2013 / Accepted: 19 December 2013 / Published: 24 December 2013
(This article belongs to the Special Issue Gene Therapy for Retroviral Infections)
Abstract
Despite the enormous success of combined anti-retroviral therapy, HIV infection is still a lifelong disease and continues to spread rapidly worldwide. There is a pressing need to develop a treatment that will cure HIV infection. Recent progress in stem cell manipulation and advancements in humanized mouse models have allowed rapid developments of gene therapy for HIV treatment. In this review, we will discuss two aspects of HIV gene therapy using human hematopoietic stem cells. The first is to generate immune systems resistant to HIV infection while the second strategy involves enhancing anti-HIV immunity to eliminate HIV infected cells. View Full-TextKeywords:
hematopoietic stem cell; HIV; gene therapy; CCR5; engineered immunity
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MDPI and ACS Style
Zhen, A.; Kitchen, S. Stem-Cell-Based Gene Therapy for HIV Infection. Viruses 2014, 6, 1-12.