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The Role of Innate Immunity in Conditioning Mosquito Susceptibility to West Nile Virus

Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
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Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Viruses 2013, 5(12), 3142-3170; https://doi.org/10.3390/v5123142
Received: 29 August 2013 / Revised: 13 November 2013 / Accepted: 9 December 2013 / Published: 13 December 2013
(This article belongs to the Special Issue West Nile Virus)
Arthropod-borne viruses (arboviruses) represent an emerging threat to human and livestock health globally. In particular, those transmitted by mosquitoes present the greatest challenges to disease control efforts. An understanding of the molecular basis for mosquito innate immunity to arbovirus infection is therefore critical to investigations regarding arbovirus evolution, virus-vector ecology, and mosquito vector competence. In this review, we discuss the current state of understanding regarding mosquito innate immunity to West Nile virus. We draw from the literature with respect to other virus-vector pairings to attempt to draw inferences to gaps in our knowledge about West Nile virus and relevant vectors. View Full-Text
Keywords: West Nile virus; innate immunity; RNAi; Toll; Imd; Jak/STAT; autophagy; apoptosis; arbovirus; mosquito West Nile virus; innate immunity; RNAi; Toll; Imd; Jak/STAT; autophagy; apoptosis; arbovirus; mosquito
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Prasad, A.N.; Brackney, D.E.; Ebel, G.D. The Role of Innate Immunity in Conditioning Mosquito Susceptibility to West Nile Virus. Viruses 2013, 5, 3142-3170.

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