Next Article in Journal
Detection and Molecular Diversity of Spike Gene of Porcine Epidemic Diarrhea Virus in China
Next Article in Special Issue
Newer Gene Editing Technologies toward HIV Gene Therapy
Previous Article in Journal
CD8 and CD4 T Cells in West Nile Virus Immunity and Pathogenesis
Article Menu

Export Article

Open AccessReview
Viruses 2013, 5(10), 2585-2600;

Foamy Virus Vectors for HIV Gene Therapy

Department of Pharmaceutical Sciences, Washington State University, Pullman, WA 99164, USA
School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA
Author to whom correspondence should be addressed.
Received: 1 September 2013 / Revised: 10 October 2013 / Accepted: 16 October 2013 / Published: 22 October 2013
(This article belongs to the Special Issue Gene Therapy for Retroviral Infections)
Full-Text   |   PDF [477 KB, uploaded 12 May 2015]   |  


Highly active antiretroviral therapy (HAART) has vastly improved outcomes for patients infected with HIV, yet it is a lifelong regimen that is expensive and has significant side effects. Retroviral gene therapy is a promising alternative treatment for HIV/AIDS; however, inefficient gene delivery to hematopoietic stem cells (HSCs) has so far limited the efficacy of this approach. Foamy virus (FV) vectors are derived from non-pathogenic viruses that are not endemic to the human population. FV vectors have been used to deliver HIV-inhibiting transgenes to human HSCs, and they have several advantages relative to other retroviral vectors. These include an attractive safety profile, broad tropism, a large transgene capacity, and the ability to persist in quiescent cells. In addition, the titers of FV vectors are not reduced by anti-HIV transgenes that affect the production of lentivirus (LV) vectors. Thus FV vectors are very promising for anti-HIV gene therapy. This review covers the advantages of FV vectors and describes their preclinical development for anti-HIV gene therapy. View Full-Text
Keywords: foamy virus; lentivirus; retrovirus; vector; gene therapy; HIV foamy virus; lentivirus; retrovirus; vector; gene therapy; HIV

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Olszko, M.E.; Trobridge, G.D. Foamy Virus Vectors for HIV Gene Therapy. Viruses 2013, 5, 2585-2600.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top