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Human Metapneumovirus Antagonism of Innate Immune Responses

1
Departments of Pediatrics, University of Texas Medical Branch at Galveston, Texas, USA
2
Microbiology and Immunology, University of Texas Medical Branch at Galveston, Texas, USA
3
Sealy Center for Molecular Medicine, University of Texas Medical Branch at Galveston, Texas, USA
*
Author to whom correspondence should be addressed.
Viruses 2012, 4(12), 3551-3571; https://doi.org/10.3390/v4123551
Received: 1 November 2012 / Revised: 20 November 2012 / Accepted: 30 November 2012 / Published: 7 December 2012
(This article belongs to the Special Issue Pneumoviruses and Metapneumoviruses)
Human metapneumovirus (hMPV) is a recently identified RNA virus belonging to the Paramyxoviridae family, which includes several major human and animal pathogens. Epidemiological studies indicate that hMPV is a significant human respiratory pathogen with worldwide distribution. It is associated with respiratory illnesses in children, adults, and immunocompromised patients, ranging from upper respiratory tract infections to severe bronchiolitis and pneumonia. Interferon (IFN) represents a major line of defense against virus infection, and in response, viruses have evolved countermeasures to inhibit IFN production as well as IFN signaling. Although the strategies of IFN evasion are similar, the specific mechanisms by which paramyxoviruses inhibit IFN responses are quite diverse. In this review, we will present an overview of the strategies that hMPV uses to subvert cellular signaling in airway epithelial cells, the major target of infection, as well as in primary immune cells. View Full-Text
Keywords: metapneumovirus; viral proteins; innate immune system; interferon antagonism metapneumovirus; viral proteins; innate immune system; interferon antagonism
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Kolli, D.; Bao, X.; Casola, A. Human Metapneumovirus Antagonism of Innate Immune Responses. Viruses 2012, 4, 3551-3571.

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