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Pathogenesis of Hepatitis C During Pregnancy and Childhood

1
Unité d'immunopathologie virale, Centre de recherche du CHU Sainte-Justine, 3175 Côte Sainte-Catherine, local 6735, Montreal, Quebec, H3T 1C5, Canada
2
Department of Microbiology & Immunology, Faculty of Medicine, Université de Montréal, C.P. 6128, Succ. Centre-ville, Montreal, Quebec, H3C 3J7, Canada
3
Department of Pediatrics, Faculty of Medicine, Université de Montréal, C.P. 6128, Succ. Centre-ville, Montreal, Quebec, H3C 3J7, Canada
*
Author to whom correspondence should be addressed.
Viruses 2012, 4(12), 3531-3550; https://doi.org/10.3390/v4123531
Received: 2 November 2012 / Revised: 18 November 2012 / Accepted: 28 November 2012 / Published: 6 December 2012
(This article belongs to the Special Issue Hepatitis C Pathology)
The worldwide prevalence of HCV infection is between 1% and 8% in pregnant women and between 0.05% and 5% in children. Yet the pathogenesis of hepatitis C during pregnancy and in the neonatal period remains poorly understood. Mother-to-child transmission (MTCT), a leading cause of pediatric HCV infection, takes place at a rate of <10%. Factors that increase the risk of MTCT include high maternal HCV viral load and coinfection with HIV-1 but, intriguingly, not breastfeeding and mode of delivery. Pharmacological prevention of MTCT is not possible at the present time because both pegylated interferon alfa and ribavirin are contraindicated for use in pregnancy and during the neonatal period. However, this may change with the recent introduction of direct acting antiviral agents. This review summarizes what is currently known about HCV infection during pregnancy and childhood. Particular emphasis is placed on how pregnancy-associated immune modulation may influence the progression of HCV disease and impact MTCT, and on the differential evolution of perinatally acquired HCV infection in children. Taken together, these developments provide insights into the pathogenesis of hepatitis C and may inform strategies to prevent the transmission of HCV from mother to child. View Full-Text
Keywords: Hepatitis C virus; pathogenesis; mother-to-child transmission; pediatrics Hepatitis C virus; pathogenesis; mother-to-child transmission; pediatrics
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MDPI and ACS Style

Le Campion, A.; Larouche, A.; Fauteux-Daniel, S.; Soudeyns, H. Pathogenesis of Hepatitis C During Pregnancy and Childhood. Viruses 2012, 4, 3531-3550.

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