Host Genetic Variants in the Pathogenesis of Hepatitis C
Abstract
:1. Introduction
2. Host Genetics as Predictive Markers for Therapy Response
2.1. Interleukin28B
Therapy response | |||
---|---|---|---|
Gene | SNP | Ref | |
Interleukin 28B | IL28B | rs12979860 | [4,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36] |
rs8099917 | [5,6,8,9,12,13,15,18,30,32,33,37,38,39,40,41,42,43] | ||
rs28416813 | [4] | ||
rs8103142 | [4,6] | ||
rs12980275 | [5,6,18] | ||
rs8105790 | [5,6,18] | ||
rs11881222 | [5] | ||
rs7248668 | [5] | ||
rs10853727 | [6,18] | ||
rs8109886 | [6] | ||
Concentrative nucleoside transporters | Slc28A2 | rs11854484 | [44,45] |
Slc28A3 | rs10868138 | [46] | |
rs56350726 | [46,45] | ||
Equilibrative nucleoside transporters | Slc29A1 | rs6932345 | [34] |
Inosine triphophatase | ITPA | rs1127354 | [45,46,47,48,49,50] |
rs7270101 | [45,46,47] | ||
Vitamin D receptor NR1I1 | VDR | rs7975232 | [51] |
rs1544410 | [51] | ||
rs731236 | [51] | ||
CYP27B1-1260 | rs10877012 | [52,53] | |
GC-globulin | rs7041 | [54] | |
rs4588 | [54] | ||
Bile salt export pump | ABCB11 | 1331 | [55,56] |
2.1.1. Geographic and Ethnic Distribution
2.1.2. IL28B in Different HCV Genotypes
2.1.3. Spontaneous Clearance and Viral Kinetics
2.1.4. Interferon Gene Expression
2.1.5. Treatment Duration
2.1.6. IL28B Genetics in Clinical Practice
2.2. Ribavirin Transporters
2.3. Inosine Triphosphatase (ITPA)
2.4. Vitamin D Receptor (VDR)
2.5. Bile Salt Export Pump (Bsep)
3. Host Genetics and Chronic Complications Such as Fibrosis Progression
Fibrosis progression | |||
---|---|---|---|
Gene | SNP | Ref | |
Interleukin 28B | IL28B | rs12979860 | [83,84,85] |
rs8099917 | [83,86,87] | ||
Vitamin D receptor NR1I1 | VDR | rs7975232 | [88] |
rs1544410 | [88] | ||
rs731236 | [88] | ||
Bile salt export pump | ABCB11 | 1331 | [89] |
Patatin-like phospholipase 3 | PNPLA3 | rs738490 | [90,91] |
Ring finger protein 7 | RNF7 | rs16851720 | [92] |
Receptor tyrosine kinase MerTK | MERTK | rs4374383 | [92] |
Tubby like protein 1 | TULP1 | rs9380516 | [92] |
3.1. IL28B
3.2. VDR
3.3. Bsep
3.4. Different Genes
4. Conclusions
Conflict of Interest
References and Notes
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Rau, M.; Baur, K.; Geier, A. Host Genetic Variants in the Pathogenesis of Hepatitis C. Viruses 2012, 4, 3281-3302. https://doi.org/10.3390/v4123281
Rau M, Baur K, Geier A. Host Genetic Variants in the Pathogenesis of Hepatitis C. Viruses. 2012; 4(12):3281-3302. https://doi.org/10.3390/v4123281
Chicago/Turabian StyleRau, Monika, Katharina Baur, and Andreas Geier. 2012. "Host Genetic Variants in the Pathogenesis of Hepatitis C" Viruses 4, no. 12: 3281-3302. https://doi.org/10.3390/v4123281