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Influenza B-Cells Protective Epitope Characterization: A Passkey for the Rational Design of New Broad-Range Anti-Influenza Vaccines

Microbiology and Virology Unit, “Vita-Salute” San Raffaele University, Milan 20132, Italy
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Viruses 2012, 4(11), 3090-3108; https://doi.org/10.3390/v4113090
Received: 28 September 2012 / Revised: 5 November 2012 / Accepted: 7 November 2012 / Published: 14 November 2012
The emergence of new influenza strains causing pandemics represents a serious threat to human health. From 1918, four influenza pandemics occurred, caused by H1N1, H2N2 and H3N2 subtypes. Moreover, in 1997 a novel influenza avian strain belonging to the H5N1 subtype infected humans. Nowadays, even if its transmission is still circumscribed to avian species, the capability of the virus to infect humans directly from avian reservoirs can result in fatalities. Moreover, the risk that this or novel avian strains could adapt to inter-human transmission, the development of resistance to anti-viral drugs and the lack of an effective prevention are all incumbent problems for the world population. In this scenario, the identification of broadly neutralizing monoclonal antibodies (mAbs) directed against conserved regions shared among influenza isolates has raised hopes for the development of monoclonal antibody-based immunotherapy and “universal” anti-influenza vaccines. View Full-Text
Keywords: monoclonal antibody; protective epitopes; heterosubtipic neutralizing activity; epitope-based influenza vaccine monoclonal antibody; protective epitopes; heterosubtipic neutralizing activity; epitope-based influenza vaccine
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MDPI and ACS Style

Clementi, N.; Criscuolo, E.; Castelli, M.; Mancini, N.; Clementi, M.; Burioni, R. Influenza B-Cells Protective Epitope Characterization: A Passkey for the Rational Design of New Broad-Range Anti-Influenza Vaccines. Viruses 2012, 4, 3090-3108. https://doi.org/10.3390/v4113090

AMA Style

Clementi N, Criscuolo E, Castelli M, Mancini N, Clementi M, Burioni R. Influenza B-Cells Protective Epitope Characterization: A Passkey for the Rational Design of New Broad-Range Anti-Influenza Vaccines. Viruses. 2012; 4(11):3090-3108. https://doi.org/10.3390/v4113090

Chicago/Turabian Style

Clementi, Nicola, Elena Criscuolo, Matteo Castelli, Nicasio Mancini, Massimo Clementi, and Roberto Burioni. 2012. "Influenza B-Cells Protective Epitope Characterization: A Passkey for the Rational Design of New Broad-Range Anti-Influenza Vaccines" Viruses 4, no. 11: 3090-3108. https://doi.org/10.3390/v4113090

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