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Viruses 2011, 3(9), 1549-1561;

Picornavirus Subversion of the Autophagy Pathway

Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Author to whom correspondence should be addressed.
Received: 9 June 2011 / Revised: 9 August 2011 / Accepted: 15 August 2011 / Published: 26 August 2011
(This article belongs to the Special Issue Autophagy and Viruses)
PDF [315 KB, uploaded 12 May 2015]


While autophagy has been shown to act as an anti-viral defense, the Picornaviridae avoid and, in many cases, subvert this pathway to promote their own replication. Evidence indicates that some picornaviruses hijack autophagy in order to induce autophagosome-like membrane structures for genomic RNA replication. Expression of picornavirus proteins can specifically induce the machinery of autophagy, although the mechanisms by which the viruses employ autophagy appear to differ. Many picornaviruses up-regulate autophagy in order to promote viral replication while some members of the family also inhibit degradation by autolysosomes. Here we explore the unusual relationship of this medically important family of viruses with a degradative mechanism of innate immunity.
Keywords: picornavirus; autophagy; membranes; viral replication picornavirus; autophagy; membranes; viral replication
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Klein, K.A.; Jackson, W.T. Picornavirus Subversion of the Autophagy Pathway. Viruses 2011, 3, 1549-1561.

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