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Viruses 2011, 3(8), 1439-1459;

Cell Surface Markers in HTLV-1 Pathogenesis

Institute of Clinical and Molecular Virology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Schlossgarten 4, 91054 Erlangen, Germany
Author to whom correspondence should be addressed.
Received: 7 July 2011 / Revised: 25 July 2011 / Accepted: 8 August 2011 / Published: 16 August 2011
(This article belongs to the Special Issue Recent Developments in HTLV Research)
PDF [484 KB, uploaded 12 May 2015]


The phenotype of HTLV-1-transformed CD4+ T lymphocytes largely depends on defined viral effector molecules such as the viral oncoprotein Tax. In this review, we exemplify the expression pattern of characteristic lineage markers, costimulatory receptors and ligands of the tumor necrosis factor superfamily, cytokine receptors, and adhesion molecules on HTLV-1-transformed cells. These molecules may provide survival signals for the transformed cells. Expression of characteristic surface markers might therefore contribute to persistence of HTLV-1-transformed lymphocytes and to the development of HTLV-1-associated disease.
Keywords: HTLV-1; Tax; oncoprotein; phenotype; differentiation; ATLL; HAM/TSP; TNFR; cytokine receptor; interleukin HTLV-1; Tax; oncoprotein; phenotype; differentiation; ATLL; HAM/TSP; TNFR; cytokine receptor; interleukin
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Kress, A.K.; Grassmann, R.; Fleckenstein, B. Cell Surface Markers in HTLV-1 Pathogenesis. Viruses 2011, 3, 1439-1459.

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