Next Article in Journal
Human T-Cell Lymphotropic Virus: A Model of NF-κB-Associated Tumorigenesis
Next Article in Special Issue
Retroviral Vectors for Analysis of Viral Mutagenesis and Recombination
Previous Article in Journal
Is Network Clustering Detectable in Transmission Trees?
Previous Article in Special Issue
Foamy Virus Biology and Its Application for Vector Development
Open AccessReview

Gammaretroviral Vectors: Biology, Technology and Application

Department of Experimental Hematology, Hannover Medical School, OE6960-HBZ, Carl-Neuberg-Strasse 1, D-30625 Hannover, Germany
Authors to whom correspondence should be addressed.
Viruses 2011, 3(6), 677-713;
Received: 8 March 2011 / Revised: 3 May 2011 / Accepted: 9 May 2011 / Published: 3 June 2011
(This article belongs to the Special Issue Retroviral Vectors)
Retroviruses are evolutionary optimized gene carriers that have naturally adapted to their hosts to efficiently deliver their nucleic acids into the target cell chromatin, thereby overcoming natural cellular barriers. Here we will review—starting with a deeper look into retroviral biology—how Murine Leukemia Virus (MLV), a simple gammaretrovirus, can be converted into an efficient vehicle of genetic therapeutics. Furthermore, we will describe how more rational vector backbones can be designed and how these so-called self-inactivating vectors can be pseudotyped and produced. Finally, we will provide an overview on existing clinical trials and how biosafety can be improved.
Keywords: Murine Leukemia Virus; gammaretroviral; split packaging design; SIN vector Murine Leukemia Virus; gammaretroviral; split packaging design; SIN vector
MDPI and ACS Style

Maetzig, T.; Galla, M.; Baum, C.; Schambach, A. Gammaretroviral Vectors: Biology, Technology and Application. Viruses 2011, 3, 677-713.

AMA Style

Maetzig T, Galla M, Baum C, Schambach A. Gammaretroviral Vectors: Biology, Technology and Application. Viruses. 2011; 3(6):677-713.

Chicago/Turabian Style

Maetzig, Tobias; Galla, Melanie; Baum, Christopher; Schambach, Axel. 2011. "Gammaretroviral Vectors: Biology, Technology and Application" Viruses 3, no. 6: 677-713.

Find Other Styles

Article Access Map by Country/Region

Only visits after 24 November 2015 are recorded.
Search more from Scilit
Back to TopTop