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Viruses 2011, 3(11), 2328-2338;

Stress Granules in the Viral Replication Cycle

Instituto de Salud Pública, Universidad Veracruzana, Av. Luis Castelazo Ayala s/n, Col. Industrial Ánimas, 91190, Xalapa, Veracruz, México
Instituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad 2001, 62210, Cuernavaca, Morelos, México
Author to whom correspondence should be addressed.
Received: 13 September 2011 / Revised: 13 November 2011 / Accepted: 14 November 2011 / Published: 18 November 2011
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As intracellular parasites, viruses require a host cell in order to replicate. However, they face a series of cellular responses against infection. One of these responses is the activation of the double-stranded RNA (dsRNA)-activated protein kinase R (PKR). PKR phosphorylates the α subunit of eukaryotic translation initiation factor 2 (eIF2α), which in turn results in global protein synthesis inhibition and formation of stress granules (SGs). Recent studies have shown that SGs can interfere with the replicative cycle of certain viruses. This review addresses how viruses have evolved different control strategies at the SG level to ensure an efficient replication cycle during the cellular stress response triggered by the viral infection.
Keywords: stress granules; stress; PKR; eIF2 stress granules; stress; PKR; eIF2
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Montero, H.; Trujillo-Alonso, V. Stress Granules in the Viral Replication Cycle. Viruses 2011, 3, 2328-2338.

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