A Potent, Broad-Spectrum Antiviral Agent that Targets Viral Membranes
Abstract
:References
- De Clercq, E. Strategies in the design of antiviral drugs. Nat. Rev. Drug Discov. 2002, 1, 13–25. [Google Scholar] [CrossRef] [PubMed]
- Johnson, E.M.; Doyle, J.D.; Wetzel, J.D.; McClung, R.P.; Katunuma, N.; Chappell, J.D.; Washington, M.K.; Dermody, T.S. Genetic and pharmacologic alteration of cathepsin expression influences reovirus pathogenesis. J. Virol. 2009, 83, 9630–9640. [Google Scholar] [CrossRef] [PubMed]
- Chandran, K.; Sullivan, N.J.; Felbor, U.; Whelan, S.P.; Cunningham, J.M. Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection. Science 2005, 308, 1643–1645. [Google Scholar] [CrossRef] [PubMed]
- Simmons, G.; Gosalia, D.N.; Rennekamp, A.J.; Reeves, J.D.; Diamond, S.L.; Bates, P. Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry. Proc. Natl. Acad. Sci. U. S. A. 2005, 102, 11876–11881. [Google Scholar] [CrossRef] [PubMed]
- Furuta, Y.; Takahashi, K.; Shiraki, K.; Sakamoto, K.; Smee, D.F.; Barnard, D.L.; Gowen, B.B.; Julander, J.G.; Morrey, J.D. T-705 (favipiravir) and related compounds: Novel broad-spectrum inhibitors of RNA viral infections. Antiviral Res. 2009, 82, 95–102. [Google Scholar] [CrossRef] [PubMed]
- Wolf, M.C.; Freiberg, A.N.; Zhang, T.; Akyol-Ataman, Z.; Grock, A.; Hong, P.W.; Li, J.; Watson, N.F.; Fang, A.Q.; Aguilar, H.C.; Porotto, M.; Honko, A.N.; Damoiseaux, R.; Miller, J.P.; Woodson, S.E.; Chantasirivisal, S.; Fontanes, V.; Negrete, O.A.; Krogstad, P.; Dasgupta, A.; Moscona, A.; Hensley, L.E.; Whelan, S.P.; Faull, K.F.; Holbrook, M.R.; Jung, M.E.; Lee, B. A broad-spectrum antiviral targeting entry of enveloped viruses. Proc. Natl. Acad. Sci. U. S. A. 2010, 107, 3157–3162. [Google Scholar] [CrossRef] [PubMed]
- Abdel-Haq, N.; Chearskul, P.; Al-Tatari, H.; Asmar, B. New antiviral agents. Indian J. Pediatr. 2006, 73, 313–321. [Google Scholar] [CrossRef] [PubMed]
- Holthuis, J.C.; Levine, T.P. Lipid traffic: floppy drives and a superhighway. Nat. Rev. Mol. Cell Biol. 2005, 6, 209–220. [Google Scholar] [CrossRef] [PubMed]
- Chernomordik, L. Non-bilayer lipids and biological fusion intermediates. Chem. Phys. Lipids 1996, 81, 203–213. [Google Scholar] [CrossRef] [PubMed]
- Udata, C.; Patel, J.; Pal, D.; Hejchman, E.; Cushman, M.; Mitra, A.K. Enhanced transport of a novel anti-HIV agent--cosalane and its congeners across human intestinal epithelial (Caco-2) cell monolayers. Int. J. Pharm. 2003, 250, 157–168. [Google Scholar] [CrossRef] [PubMed]
- Cushman, M.; Golebiewski, W.M.; McMahon, J.B.; Buckheit Jr., R.W.; Clanton, D.J.; Weislow, O.; Haugwitz, R.D.; Bader, J.P.; Graham, L.; Rice, W.G. Design, synthesis, and biological evaluation of cosalane, a novel anti-HIV agent which inhibits multiple features of virus reproduction. J. Med. Chem. 1994, 37, 3040–3050. [Google Scholar] [CrossRef] [PubMed]
- Katz, D.H.; Marcelletti, J.F.; Pope, L.E.; Khalil, M.H.; Katz, L.R.; McFadden, R. n-docosanol: broad spectrum anti-viral activity against lipid-enveloped viruses. Ann. N. Y. Acad. Sci. 1994, 724, 472–488. [Google Scholar] [CrossRef] [PubMed]
- Boriskin, Y.S.; Leneva, I.A.; Pecheur, E.I.; Polyak, S.J. Arbidol: a broad-spectrum antiviral compound that blocks viral fusion. Curr. Med. Chem. 2008, 15, 997–1005. [Google Scholar] [CrossRef] [PubMed]
- Pecheur, E.I.; Lavillette, D.; Alcaras, F.; Molle, J.; Boriskin, Y.S.; Roberts, M.; Cosset, F.L.; Polyak, S.J. Biochemical mechanism of hepatitis C virus inhibition by the broad-spectrum antiviral arbidol. Biochemistry 2007, 46, 6050–6059. [Google Scholar] [CrossRef] [PubMed]
- Butcher, E.C. Can cell systems biology rescue drug discovery? Nat. Rev. Drug Discov. 2005, 4, 461–467. [Google Scholar] [CrossRef] [PubMed]
© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Share and Cite
Wojcechowskyj, J.A.; Doms, R.W. A Potent, Broad-Spectrum Antiviral Agent that Targets Viral Membranes. Viruses 2010, 2, 1106-1109. https://doi.org/10.3390/v2051106
Wojcechowskyj JA, Doms RW. A Potent, Broad-Spectrum Antiviral Agent that Targets Viral Membranes. Viruses. 2010; 2(5):1106-1109. https://doi.org/10.3390/v2051106
Chicago/Turabian StyleWojcechowskyj, Jason A., and Robert W. Doms. 2010. "A Potent, Broad-Spectrum Antiviral Agent that Targets Viral Membranes" Viruses 2, no. 5: 1106-1109. https://doi.org/10.3390/v2051106