Next Article in Journal
Insights into Arbovirus Evolution and Adaptation from Experimental Studies
Next Article in Special Issue
The Pathogenesis of Rift Valley Fever
Previous Article in Journal
Buying Time—The Immune System Determinants of the Incubation Period to Respiratory Viruses
Open AccessReview

Hantaviruses in the Americas and Their Role as Emerging Pathogens

1
Center for Infectious Diseases and Immunity, Department of Pathology, University of New Mexico Health Sciences Center, MSC08 4640, Albuquerque, New Mexico 87131, USA
2
Biology Department, University of New Mexico, MSC03 2020, Albuquerque, New Mexico 87131, USA
*
Author to whom correspondence should be addressed.
Viruses 2010, 2(12), 2559-2586; https://doi.org/10.3390/v2122559
Received: 25 October 2010 / Revised: 15 November 2010 / Accepted: 24 November 2010 / Published: 25 November 2010
(This article belongs to the Special Issue Pathogenesis of Emerging and Re-Emerging RNA Viruses)
The continued emergence and re-emergence of pathogens represent an ongoing, sometimes major, threat to populations. Hantaviruses (family Bunyaviridae) and their associated human diseases were considered to be confined to Eurasia, but the occurrence of an outbreak in 1993–94 in the southwestern United States led to a great increase in their study among virologists worldwide. Well over 40 hantaviral genotypes have been described, the large majority since 1993, and nearly half of them pathogenic for humans. Hantaviruses cause persistent infections in their reservoir hosts, and in the Americas, human disease is manifest as a cardiopulmonary compromise, hantavirus cardiopulmonary syndrome (HCPS), with case-fatality ratios, for the most common viral serotypes, between 30% and 40%. Habitat disturbance and larger-scale ecological disturbances, perhaps including climate change, are among the factors that may have increased the human caseload of HCPS between 1993 and the present. We consider here the features that influence the structure of host population dynamics that may lead to viral outbreaks, as well as the macromolecular determinants of hantaviruses that have been regarded as having potential contribution to pathogenicity.
Keywords: hantavirus; hantavirus cardiopulmonary syndrome; emergence; pathology; epidemiology hantavirus; hantavirus cardiopulmonary syndrome; emergence; pathology; epidemiology
MDPI and ACS Style

Hjelle, B.; Torres-Pérez, F. Hantaviruses in the Americas and Their Role as Emerging Pathogens. Viruses 2010, 2, 2559-2586.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop