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Viruses
Volume 17
Issue 5
10.3390/v17050662
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Review

HPV-Driven Head and Neck Cancer: The European Perspective

by
Wojciech Golusiński
1,2,
Ewelina Golusińska-Kardach
3,
Piotr Machczyński
1,2 and
Mateusz Szewczyk
1,2,*
1
Department of Head and Neck Surgery, University of Medical Sciences, 61-701Poznan, Poland
2
The Greater Poland Cancer Centre, Poznan, Poland
3
Department and Clinic of Dental Surgery, Periodontal Diseases and Oral Mucosa, Poznan University of Medical Sciences, 60-812 Poznan, Poland
*
Author to whom correspondence should be addressed.
Viruses 2025, 17(5), 662; https://doi.org/10.3390/v17050662
Submission received: 19 March 2025 / Revised: 24 April 2025 / Accepted: 26 April 2025 / Published: 30 April 2025
(This article belongs to the Section Human Virology and Viral Diseases)
Review Reports Versions Notes

Abstract

Head and neck squamous-cell carcinoma (HNSCC) has long been associated with tobacco and alcohol use. In the last two decades, however, human papillomavirus (HPV) infection has emerged as an important driver of these cancers, particularly in the oropharynx. The eighth edition of the American Joint Committee on Cancer (AJCC) staging system now defines HPV+ and HPV−OPSCC as separate entities. Although our understanding of HPV+ HNSCC continues to improve, it can be challenging to keep up to date with the growing body of evidence. In this context, the present narrative review was carried out to provide an overview of HPV-driven head and neck cancer, with an emphasis on Europe. We review the latest evidence on epidemiology, diagnosis, and treatment, including recent trends towards treatment de-intensification and future directions.
Keywords: HPV; oropharynx; epidemiology; Europe; head neck HPV; oropharynx; epidemiology; Europe; head neck

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MDPI and ACS Style

Golusiński, W.; Golusińska-Kardach, E.; Machczyński, P.; Szewczyk, M. HPV-Driven Head and Neck Cancer: The European Perspective. Viruses 2025, 17, 662. https://doi.org/10.3390/v17050662

AMA Style

Golusiński W, Golusińska-Kardach E, Machczyński P, Szewczyk M. HPV-Driven Head and Neck Cancer: The European Perspective. Viruses. 2025; 17(5):662. https://doi.org/10.3390/v17050662

Chicago/Turabian Style

Golusiński, Wojciech, Ewelina Golusińska-Kardach, Piotr Machczyński, and Mateusz Szewczyk. 2025. "HPV-Driven Head and Neck Cancer: The European Perspective" Viruses 17, no. 5: 662. https://doi.org/10.3390/v17050662

APA Style

Golusiński, W., Golusińska-Kardach, E., Machczyński, P., & Szewczyk, M. (2025). HPV-Driven Head and Neck Cancer: The European Perspective. Viruses, 17(5), 662. https://doi.org/10.3390/v17050662

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