The Epidemiology of Hepatitis E in Israel and Potential Risk Factors: A Cross-Sectional Population-Based Serological Survey of Hepatitis E Virus in Northern Israel
Abstract
:1. Introduction
2. Methods
2.1. Study Population
2.2. HEV Laboratory Diagnosis
2.3. Hot Spot Analysis
2.4. Statistical Analysis
2.5. Ethical Aspects
3. Results
3.1. Description of the Study Population
3.2. HEV Seroprevalence Results
3.3. Spatial Analysis
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Data Availability Statement
Conflicts of Interest
References
- Smith, D.B.; Izopet, J.; Nicot, F.; Simmonds, P.; Jameel, S.; Meng, X.-J.; Norder, H.; Okamoto, H.; van der Poel, W.H.; Reuter, G.; et al. Update: Proposed reference sequences for subtypes of hepatitis E virus (species Orthohepevirus A). J. Gen. Virol. 2020, 101, 692–698. [Google Scholar] [CrossRef] [PubMed]
- Purdy, M.A.; Drexler, J.F.; Meng, X.-J.; Norder, H.; Okamoto, H.; Van der Poel, W.H.M.; Reuter, G.; de Souza, W.M.; Ulrich, R.G.; Smith, D.B. ICTV Virus Taxonomy Profile: Hepeviridae 2022. J. Gen. Virol. 2022, 103, 001778. [Google Scholar] [CrossRef]
- Kamani, L.; Padhani, Z.A.; Das, J.K. Hepatitis E: Genotypes, strategies to prevent and manage, and the existing knowledge gaps. JGH Open 2021, 5, 1127–1134. [Google Scholar] [CrossRef]
- Lee, G.-H.; Tan, B.-H.; Teo, E.C.-Y.; Lim, S.-G.; Dan, Y.-Y.; Wee, A.; Aw, P.P.K.; Zhu, Y.; Hibberd, M.L.; Tan, C.-K.; et al. Chronic Infection with Camelid Hepatitis E Virus in a Liver Transplant Recipient Who Regularly Consumes Camel Meat and Milk. Gastroenterology 2016, 150, 355–357.e3. [Google Scholar] [CrossRef] [PubMed]
- Khuroo, M.; Khuroo, M.; Khuroo, N. Transmission of Hepatitis E Virus in Developing Countries. Viruses 2016, 8, 253. [Google Scholar] [CrossRef] [PubMed]
- Yugo, D.; Meng, X.-J. Hepatitis E Virus: Foodborne, Waterborne and Zoonotic Transmission. Int. J. Environ. Res. Public. Health 2013, 10, 4507–4533. [Google Scholar] [CrossRef]
- Squire, L.R. The legacy of patient H.M. for neuroscience. NIH Public Access Neuron. 2009, 61, 6–9. [Google Scholar] [CrossRef]
- Dalton, H.R.; Kamar, N.; Baylis, S.A.; Moradpour, D.; Wedemeyer, H.; Negro, F. EASL Clinical Practice Guidelines on hepatitis E virus infection. J. Hepatol. 2018, 68, 1256–1271. [Google Scholar] [CrossRef]
- Kar, P.; Karna, R. A Review of the Diagnosis and Management of Hepatitis E. Curr. Treat. Options Infect. Dis. 2020, 12, 310–320. [Google Scholar] [CrossRef]
- Kamar, N.; Selves, J.; Mansuy, J.-M.; Ouezzani, L.; Péron, J.-M.; Guitard, J.; Cointault, O.; Esposito, L.; Abravanel, F.; Danjoux, M.; et al. Hepatitis E Virus and Chronic Hepatitis in Organ-Transplant Recipients. N. Engl. J. Med. 2008, 358, 811–817. [Google Scholar] [CrossRef]
- Hartl, J.; Otto, B.; Madden, R.G.; Webb, G.; Woolson, K.L.; Kriston, L.; Vettorazzi, E.; Lohse, A.W.; Dalton, H.R.; Pischke, S. Hepatitis E Seroprevalence in Europe: A Meta-Analysis. Viruses 2016, 8, 211. [Google Scholar] [CrossRef] [PubMed]
- Li, P.; Liu, J.; Li, Y.; Su, J.; Ma, Z.; Bramer, W.M.; Cao, W.; de Man, R.A.; Peppelenbosch, M.P.; Pan, Q. The global epidemiology of hepatitis E virus infection: A systematic review and meta-analysis. Liver Int. 2020, 40, 1516–1528. [Google Scholar] [CrossRef] [PubMed]
- Faber, M.S.; Wenzel, J.J.; Jilg, W.; Thamm, M.; Höhle, M.; Stark, K. Hepatitis E Virus Seroprevalence among Adults, Germany. Emerg. Infect. Dis. 2012, 18, 1654–1657. [Google Scholar] [CrossRef] [PubMed]
- Christensen, P.B.; Engle, R.E.; Hjort, C.; Homburg, K.M.; Vach, W.; Georgsen, J.; Purcell, R.H. Time Trend of the Prevalence of Hepatitis E Antibodies amongFarmers and Blood Donors: A Potential Zoonosis in Denmark. Clin Infect Dis. 2008, 47, 1026–1031. [Google Scholar] [CrossRef]
- Dalton, H.R.; Stableforth, W.; Thurairajah, P.; Hazeldine, S.; Remnarace, R.; Usama, W.; Farrington, L.; Hamad, N.; Sieberhagen, C.; Ellis, V.; et al. Autochthonous hepatitis E in Southwest England: Natural history, complications and seasonal variation, and hepatitis E virus IgG seroprevalence in blood donors, the elderly and patients with chronic liver disease. Eur. J. Gastroenterol. Hepatol. 2008, 20, 784–790. [Google Scholar] [CrossRef]
- Denner, J.; Pischke, S.; Steinmann, E.; Blümel, J.; Glebe, D. Why all blood donations should be tested for hepatitis E virus (HEV). BMC Infect. Dis. 2019, 19, 541. [Google Scholar] [CrossRef]
- Hewitt, P.E.; Ijaz, S.; Brailsford, S.R.; Brett, R.; Dicks, S.; Haywood, B.; Kennedy, I.T.R.; Kitchen, A.; Patel, P.; Poh, J.; et al. Hepatitis E virus in blood components: A prevalence and transmission study in southeast England. Lancet 2014, 384, 1766–1773. [Google Scholar] [CrossRef]
- Mor, O.; Bassal, R.; Michaeli, M.; Wax, M.; Ram, D.; Cohen-Ezra, O.; Cohen, D.; Mendelson, E.; Ben-Ari, Z.; Shohat, T. Prevalence of Hepatitis E Virus Antibodies, Israel, 2009–2010. Emerg. Infect. Dis. 2015, 21, 692–694. [Google Scholar] [CrossRef]
- Ram, D.; Gozlan, Y.; Mendelson, E.; Mor, O.; Ben-Ari, Z.; Schwartz, E.; Manor, Y. Hepatitis E Virus Genotype 3 in Sewage and Genotype 1 in Acute Hepatitis Cases, Israel. Am. J. Trop. Med. Hyg. 2016, 95, 216–220. [Google Scholar] [CrossRef]
- Shirazi, R.; Pozzi, P.; Wax, M.; Bar-Or, I.; Asulin, E.; Lustig, Y.; Mendelson, E.; Ben-Ari, Z.; Schwartz, E.; Mor, O. Hepatitis E in pigs in Israel: Seroprevalence, molecular characterisation and potential impact on humans. Eurosurveillance 2018, 23, 1800067. [Google Scholar] [CrossRef]
- Bassal, R.; Wax, M.; Shirazi, R.; Shohat, T.; Cohen, D.; David, D.; Abu-Mouch, S.; Abu-Ghanem, Y.; Mendelson, E.; Ben-Ari, Z.; et al. Seroprevalence of hepatitis E virus in dromedary camels, Bedouins, Muslim Arabs and Jews in Israel, 2009–2017. Epidemiol. Infect. 2019, 147, e92. [Google Scholar] [CrossRef] [PubMed]
- Central Bureau of Statistics, Israel. Population. Statistical Abstracts of Israel, No. 64. 2017. Available online: https://www.cbs.gov.il/he/cbsnewbrand/Pages/default.aspx (accessed on 1 January 2017).
- Drobeniuc, J.; Meng, J.; Reuter, G.; Greene-Montfort, T.; Khudyakova, N.; Dimitrova, Z.; Kamili, S.; Teo, C. Serologic Assays Specific to Immunoglobulin M Antibodies against Hepatitis E Virus: Pangenotypic Evaluation of Performances. Clin. Infect. Dis. 2010, 51, e24–e27. [Google Scholar] [CrossRef]
- Anselin, L.; Getis, A. Spatial statistical analysis and geographic information systems. Ann. Reg. Sci. 1992, 26, 19–33. [Google Scholar] [CrossRef]
- Mitchell, A. The ESRI Guide to GIS Analysis Volume 3: Modeling Sustainability, Movement, and Interaction; Esri Press: Redlands, CA, USA, 2012; Volume 3, p. 419. [Google Scholar]
- Chen, C.; Zhao, N.; Yue, T.; Guo, J. A generalization of inverse distance weighting method via kernel regression and its application to surface modeling. Arab. J. Geosci. 2015, 8, 6623–6633. [Google Scholar] [CrossRef]
- Beyer, S.; Szewzyk, R.; Gnirss, R.; Johne, R.; Selinka, H.-C. Detection and Characterization of Hepatitis E Virus Genotype 3 in Wastewater and Urban Surface Waters in Germany. Food Environ. Virol. 2020, 12, 137–147. [Google Scholar] [CrossRef] [PubMed]
- Miura, T.; Lhomme, S.; Le Saux, J.-C.; Le Mehaute, P.; Guillois, Y.; Couturier, E.; Izopet, J.; Abranavel, F.; Le Guyader, F.S. Detection of Hepatitis E Virus in Sewage After an Outbreak on a French Island. Food Environ. Virol. 2016, 8, 194–199. [Google Scholar] [CrossRef]
- Chang, Y.; Wang, L.; Geng, J.; Zhu, Y.; Fu, H.; Ren, F.; Li, L.; Wang, X.; Zhuang, H. Zoonotic risk of hepatitis E virus (HEV): A study of HEV infection in animals and humans in suburbs of Beijing. Hepatol. Res. 2009, 39, 1153–1158. [Google Scholar] [CrossRef] [PubMed]
- Kim, B.-S.; Lim, H.-S.; Lee, K.; Min, Y.-S.; Yoon, Y.-S.; Jeong, H.-S. A Survey on the Status of Hepatitis E Virus Infection among the Slaughterhouse Workers in Korea. J. Prev. Med. Public Health 2015, 48, 53–61. [Google Scholar] [CrossRef]
- Meng, X.J. Hepatitis E virus: Animal reservoirs and zoonotic risk. Vet. Microbiol. 2010, 140, 256–265. [Google Scholar] [CrossRef]
Variables | Total Sample N = 716 | |
---|---|---|
Sex | Male | 304 (42.5) |
Female | 412 (57.5) | |
Age (years) | 18–34 | 260 (36.3) |
35–54 | 263 (36.7) | |
55–74 | 145 (20.3) | |
75+ | 48 (6.7) | |
Ethnicity | Arab | 335 (46.8) |
Jewish | 381 (53.2) | |
Place of residence | Village | 314 (43.8) |
City | 402 (56.2) | |
Socioeconomic status | Low rank 1–3 | 184 (25.7) |
Intermediate, high rank 4–10 | 532 (74.3) |
All | Standardized Rate (per 100) 95% CI |
---|---|
Standardized by age, sex, and ethnicity group 1 | 9.8 (6.9–12.8) |
Standardized by age 2 | 11.9 (9.2–14.6) |
Standardized by sex 3 | 10.4 (8.3–12.8) |
Standardized by ethnicity 4 | 9.4 (6.9–11.9) |
Crude Rate (per 100) 95% CI | Standardized Rate 1 (per 100) 95%CI | Standardized Rate Ratio 95% CI | |
---|---|---|---|
All | 10.4 (8.5–13.0) | 11.9 (9.2–14.6) | - |
Female | 10.9 (8.3–14.4) | 12.6 (8. 9–16.3) | 1.16 (0.73–1.85) |
Male 2 | 9.8 (6.9–13.7) | 10.9 (6.9–14.8) | 1 |
Arabs | 12.5 (9.4–16.6) | 17.5 (11.9–23.1) | 2.02 (1.26–3.22) |
Jews 2 | 8.6 (6.3–12.0) | 8.6 (5.7–11.6) | 1 |
Variables | Negative IgG HEV N = 641 | Positive IgG HEV N = 75 | Univariable Models OR (95% CI) | Multivariable Model OR (95% CI) | |
---|---|---|---|---|---|
Sex | Male | 276 (43.1) | 30 (40.0) | 1 | 1 |
Female | 365 (56.9) | 45 (60.0) | 1.13 (0.69–1.85) | 1.23 (0.74–2.12) | |
Age (years) | 18–34 | 253 (39.4) | 7 (9.3) | 1 | 1 |
35–54 | 249 38.9) | 14 18.7) | 2.03 (0.81–5.12) | 2.46 (0.96–6.30) | |
55–74 | 114 (17.8) | 31 (41.3) | 9.83 (4.20–22.98) | 14.38 (5.87–35.25) | |
75+ | 25 (3.9) | 23 (30.7) | 33.25 (12.98–85.17) | 59.05 (21.11–165.13) | |
Ethnicity | Arab | 293 (45.7) | 42 (56.0) | 1 | 1 |
Jewish | 348 (54.3) | 33 (44.0) | 0.66 (0.41–1.07) | 0.57 (0.26–1.24) | |
Place of residence | Village | 274 (42.8) | 40 (53.3) | 1 | 1 |
City | 367 (57.2) | 35 (46.7) | 0.65 (0.40–1.06) | 0.96 (0.46–1.99) | |
Socioeconomic status | Low rank 1–3 | 160 (24.9) | 24 (32.0) | 1 | 1 |
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Daniel, R.; Zelber-Sagi, S.; Barak, M.; Zuckerman, E. The Epidemiology of Hepatitis E in Israel and Potential Risk Factors: A Cross-Sectional Population-Based Serological Survey of Hepatitis E Virus in Northern Israel. Viruses 2025, 17, 536. https://doi.org/10.3390/v17040536
Daniel R, Zelber-Sagi S, Barak M, Zuckerman E. The Epidemiology of Hepatitis E in Israel and Potential Risk Factors: A Cross-Sectional Population-Based Serological Survey of Hepatitis E Virus in Northern Israel. Viruses. 2025; 17(4):536. https://doi.org/10.3390/v17040536
Chicago/Turabian StyleDaniel, Rasha, Shira Zelber-Sagi, Mira Barak, and Eli Zuckerman. 2025. "The Epidemiology of Hepatitis E in Israel and Potential Risk Factors: A Cross-Sectional Population-Based Serological Survey of Hepatitis E Virus in Northern Israel" Viruses 17, no. 4: 536. https://doi.org/10.3390/v17040536
APA StyleDaniel, R., Zelber-Sagi, S., Barak, M., & Zuckerman, E. (2025). The Epidemiology of Hepatitis E in Israel and Potential Risk Factors: A Cross-Sectional Population-Based Serological Survey of Hepatitis E Virus in Northern Israel. Viruses, 17(4), 536. https://doi.org/10.3390/v17040536