Association between the Mode of Delivery and Vertical Transmission of Human Papillomavirus
Abstract
:1. Introduction
2. Materials and Methods
2.1. Participants
2.2. Data Collection
2.3. HPV Testing and Genotyping
2.4. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Baseline Characteristics | Vaginal Delivery (n = 201) | Caesarean Section (n = 81) | All Participants (n = 282) |
---|---|---|---|
Age | |||
Median (IQR) | 30 (27–33) | 32 (29–35) | 31 (28–34) |
Range | 19–43 | 20–47 | 19–47 |
Age category, n (%) | |||
25 and under | 29 (14.4%) | 6 (7.4%) | 35 (12.4%) |
26–35 | 147 (73.1%) | 57 (70.4%) | 204 (72.3%) |
36 and over | 25 (12.4%) | 18 (22.2%) | 43 (15.3%) |
Ethnicity, n (%) | |||
Caucasian | 164 (81.6%) | 58 (71.6%) | 222 (78.7%) |
Other | 37 (18.4%) | 23 (28.4%) | 60 (21.3%) |
In a relationship with a partner, n (%) | |||
Yes | 178 (88.6%) | 76 (93.8%) | 254 (90.1%) |
No | 23 (11.4%) | 5 (6.2%) | 28 (9.9%) |
Some university education, n (%) | |||
Yes | 123 (61.2%) | 44 (54.3%) | 167 (59.2%) |
No | 78 (38.8%) | 37 (45.7%) | 115 (40.8%) |
Annual household income (CAD), n (%) | |||
≤39,000 | 33 (17.2%) | 11 (14.3%) | 44 (16.4%) |
40,000–59,999 | 30 (15.6%) | 15 (19.5%) | 45 (16.7%) |
60,000–99,999 | 56 (29.2%) | 20 (26%) | 76 (28.3%) |
≥100,000 | 73 (38%) | 31 (40.3%) | 104 (38.7%) |
Missing | 9 | 4 | 13 |
Smoking status, n (%) | |||
Current | 36 (17.9%) | 8 (9.9%) | 44 (15.6%) |
Former | 40 (19.9%) | 16 (19.8%) | 56 (19.9%) |
Never | 125 (62.2%) | 57 (70.4%) | 182 (64.5%) |
Vaccinated against HPV, n (%) | |||
Yes | 27 (14.3%) | 10 (13.3%) | 37 (14%) |
No | 162 (85.7%) | 65 (86.7%) | 227 (86%) |
Missing | 12 | 6 | 18 |
Parity, n (%) | |||
Nulliparity | 101 (55.2%) | 42 (55.3%) | 143 (55.2%) |
Multiparity | 82 (44.8%) | 34 (44.7%) | 116 (44.8%) |
Missing | 18 | 5 | 23 |
Any new sexual partner in the past year, n (%) | |||
Yes | 26 (12.9%) | 9 (11.1%) | 35 (12.4%) |
No | 175 (87.1%) | 72 (88.9%) | 247 (87.6%) |
Characteristics during pregnancy | |||
Gestational age, delivery | |||
Mean (SD) | 39.4 (1.37) | 38.8 (2.27) | 39.3 (1.70) |
Median (IQR) | 39.6 (38.6-40.4) | 39.1 (38-40.4) | 39.5 (38.4-40.4) |
Range | 34.6-41.9 | 30.7-42 | 30.7-42 |
Maternal HR-HPV, n (%) | |||
Any HR-HPV at 1st trimester | 148 (73.6%) | 54 (66.7%) | 202 (71.6%) |
Any HR-HPV at 3rd trimester | 147 (73.1%) | 49 (60.5%) | 196 (69.5%) |
Maternal multiple infection, n (%) | |||
Multiple infection at 1st trimester | 100 (49.8%) | 46 (56.8%) | 146 (51.8%) |
Multiple infection at 3rd trimester | 81 (40.3%) | 41 (50.6%) | 122 (43.3%) |
ID | Mode of Delivery | Genotype Detected | Site in Baby * | Concordant Pair | |||
---|---|---|---|---|---|---|---|
Mother, Baseline | Mother, 3rd Trimester | Infant, 36–48 h after Birth | Infant, 3 Months | ||||
1 | Caesarean section | 53 | 59 | 84 | - | O | No |
2 | Caesarean section | 54 | 54, 83 | 82 | - | O | No |
3 | Caesarean section | 66 | 58, 66 | 73 | MV | G | No |
4 | Vaginal | 53, 59, 89 | 53, 89 | 51 | MV | E | No |
5 | Vaginal | 89 | 89 | - | 89 | O | Yes |
6 | Vaginal | 66, 70, 89 | 66 | MV | 66 | O, E | Yes |
7 | Vaginal | 31, 35, 42, 51, 53, 58 | 31, 35, 42, 51, 53, 58, 84 | 39, 42 | - | O, P, G | Yes |
8 | Vaginal | 31, 40, 45, 54, 59, 67, 81, 83 | 31, 40, 81, 83, 89 | - | 89 | O | Yes |
9 | Vaginal | 35, 45, 61 | 35, 45, 89 | 35 | MV | G | Yes |
10 | Vaginal | 6, 39 | 6, 39 | 6 | - | E | Yes |
11 | Vaginal | 39, 59 | 31, 66 | 31, 66 | - | E | Yes |
12 | Vaginal | 66 | 66 | 66 | MV | P, E | Yes |
13 | Vaginal | 45, 62 | 45, 62 | 62 | - | G | Yes |
14 | Vaginal | 18 | 18 | 18 | - | O | Yes |
15 | Vaginal | 51 | 51 | 51 | - | G, E | Yes |
16 | Vaginal | 40, 42, 71, 83 | 40, 62, 71, 73 | 62 | - | E | Yes |
17 | Vaginal | 66 | 66 | 66 | - | E | Yes |
18 | Vaginal | 16, 35, 42, 52 | 16, 35, 52 | 16, 35, 52 | - | G | Yes |
19 | Vaginal | 39, 66 | 31, 39, 66 | 66 | - | G | Yes |
20 | Vaginal | 16, 18, 45, 53, 82 | 16, 45, 53 | 16, 53 | - | O | Yes |
21 | Vaginal | 42, 83, 84, 89 | 26, 42, 83, 84, 89 | 83 | MV | P | Yes |
22 | Vaginal | 35, 44, 52, 56 | 35, 44, 52, 56, 89 | 44 | 52 | E | Yes |
23 | Vaginal | 16, 62, 81 | 16, 62, 81 | 16, 62 | MV | O, G, E | Yes |
24 | Vaginal | 34, 53, 89 | 66, 84, 89 | 84 | - | E | Yes |
25 | Vaginal | 51, 84 | 51 | - | 51 | O | Yes |
Exposure | n | Cases of HPV in Infants n (%) | Crude OR (95% CI) | Adjusted OR (95% CI) |
---|---|---|---|---|
Caesarean section | 81 | 3 (3.7) | 1 | 1 A |
Vaginal delivery | 201 | 22 (10.9) | 3.20 (0.93–10.99) | 3.63 (1.03–12.82) |
Elective caesarean section (intact membranes) | 38 | 1 (2.6) | 1 | 1 B |
Caesarean section after rupture of membranes | 43 | 2 (4.7) | 1.80 (0.16–20.73) | 1.31 (0.10–17.76) |
Vaginal delivery | 201 | 22 (10.9) | 4.55 (0.59–34.80) | 4.14 (0.46–38.99) |
Time between rupture of membranes and birth | 240 * | 24 (10.0) | 1.00 (0.97–1.02) | - C |
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Nantel, É.; Mayrand, M.-H.; Audibert, F.; Niyibizi, J.; Brassard, P.; Laporte, L.; Lacaille, J.; Zahreddine, M.; Fraser, W.; Francoeur, D.; et al. Association between the Mode of Delivery and Vertical Transmission of Human Papillomavirus. Viruses 2024, 16, 303. https://doi.org/10.3390/v16020303
Nantel É, Mayrand M-H, Audibert F, Niyibizi J, Brassard P, Laporte L, Lacaille J, Zahreddine M, Fraser W, Francoeur D, et al. Association between the Mode of Delivery and Vertical Transmission of Human Papillomavirus. Viruses. 2024; 16(2):303. https://doi.org/10.3390/v16020303
Chicago/Turabian StyleNantel, Émilie, Marie-Hélène Mayrand, François Audibert, Joseph Niyibizi, Paul Brassard, Louise Laporte, Julie Lacaille, Monica Zahreddine, William Fraser, Diane Francoeur, and et al. 2024. "Association between the Mode of Delivery and Vertical Transmission of Human Papillomavirus" Viruses 16, no. 2: 303. https://doi.org/10.3390/v16020303
APA StyleNantel, É., Mayrand, M.-H., Audibert, F., Niyibizi, J., Brassard, P., Laporte, L., Lacaille, J., Zahreddine, M., Fraser, W., Francoeur, D., Bédard, M.-J., Girard, I., Lacroix, J., Carceller, A. M., Coutlée, F., & Trottier, H., on behalf of the HERITAGE Study Group. (2024). Association between the Mode of Delivery and Vertical Transmission of Human Papillomavirus. Viruses, 16(2), 303. https://doi.org/10.3390/v16020303