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Review
Peer-Review Record

The Effects of Viral Structural Proteins on Acidic Phospholipids in Host Membranes

Viruses 2024, 16(11), 1714; https://doi.org/10.3390/v16111714
by Ricardo de Souza Cardoso and Akira Ono *
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Viruses 2024, 16(11), 1714; https://doi.org/10.3390/v16111714
Submission received: 13 September 2024 / Revised: 23 October 2024 / Accepted: 28 October 2024 / Published: 31 October 2024
(This article belongs to the Special Issue Host Membranes and Virus Infection Cycle)

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

This is an interesting and informative review on the role of acidic lipids in the assembly of IAV and HIV-1.

Regarding IAV, it might be interesting to mention whether NA also might interact with acidic lipids. 

Also, what about the role of positively charged lipids in electrostatic interactions with proteins? Although I know that such lipids are very few...

Readers might appreciate information regarding the charge of the discussed lipids. Is that easy? At pH 7 ca., PS has a -1 charge, like e.g. PI3P, and PI45P has a -2 charge?

Regarding the paragraph starting on line 398-9. I guess many viruses, including IAV, induce apoptosis and PS exposure.  So what is described here for HIV should also hold true for IAV, shouldn´t it?

Typos on line 214 and 251.

Line 253, there is no Figure 1F

Author Response

We thank the reviewers for the thorough assessment of our manuscript and helpful suggestions. Please see the attachment for our response to each of the reviewers' comments.

Author Response File: Author Response.pdf

Reviewer 2 Report

Comments and Suggestions for Authors

NA

Comments for author File: Comments.pdf

Comments on the Quality of English Language

NA

Author Response

We thank the reviewers for the thorough assessment of our manuscript and helpful suggestions. Please see the attachment for our response to each of the reviewers' comments.

Author Response File: Author Response.pdf

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