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Review

Epstein–Barr Virus History and Pathogenesis

1
Department of Hematology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing 210029, China
2
Departments of Otorhinolaryngology-Head and Neck Surgery, and Microbiology, The Tumor Virology Program, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA
*
Authors to whom correspondence should be addressed.
Viruses 2023, 15(3), 714; https://doi.org/10.3390/v15030714
Submission received: 26 January 2023 / Revised: 4 March 2023 / Accepted: 7 March 2023 / Published: 9 March 2023
(This article belongs to the Special Issue Epstein-Barr Virus Replication and Pathogenesis)

Abstract

Epstein–Barr virus (EBV) is the first identified human oncogenic virus that can establish asymptomatic life-long persistence. It is associated with a large spectrum of diseases, including benign diseases, a number of lymphoid malignancies, and epithelial cancers. EBV can also transform quiescent B lymphocytes into lymphoblastoid cell lines (LCLs) in vitro. Although EBV molecular biology and EBV-related diseases have been continuously investigated for nearly 60 years, the mechanism of viral-mediated transformation, as well as the precise role of EBV in promoting these diseases, remain a major challenge yet to be completely explored. This review will highlight the history of EBV and current advances in EBV-associated diseases, focusing on how this virus provides a paradigm for exploiting the many insights identified through interplay between EBV and its host during oncogenesis, and other related non-malignant disorders.
Keywords: Epstein-Barr virus; pathogenesis; cancer induction; lymphoma; epithelial carcinoma Epstein-Barr virus; pathogenesis; cancer induction; lymphoma; epithelial carcinoma

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MDPI and ACS Style

Yu, H.; Robertson, E.S. Epstein–Barr Virus History and Pathogenesis. Viruses 2023, 15, 714. https://doi.org/10.3390/v15030714

AMA Style

Yu H, Robertson ES. Epstein–Barr Virus History and Pathogenesis. Viruses. 2023; 15(3):714. https://doi.org/10.3390/v15030714

Chicago/Turabian Style

Yu, Hui, and Erle S. Robertson. 2023. "Epstein–Barr Virus History and Pathogenesis" Viruses 15, no. 3: 714. https://doi.org/10.3390/v15030714

APA Style

Yu, H., & Robertson, E. S. (2023). Epstein–Barr Virus History and Pathogenesis. Viruses, 15(3), 714. https://doi.org/10.3390/v15030714

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