Next Article in Journal
Bacteriophage P22 Capsid as a Pluripotent Nanotechnology Tool
Previous Article in Journal
Updates and New Perspectives on Adenoviral Gene Therapy and Vaccine Vectors
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Viruses
Volume 15
Issue 2
10.3390/v15020515
viruses-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

The Synergy of Chicken Anemia Virus and Gyrovirus Homsa 1 in Chickens

by
Mengzan Yang
,
Qi Yang
,
Xiaoqing Bi
,
Hengyang Shi
,
Jianhao Yang
,
Xiangyu Cheng
,
Tianxing Yan
,
Honghai Zhang
and
Ziqiang Cheng
*
College of Veterinary Medicine, Shandong Agricultural University, Tai’an 271018, China
*
Author to whom correspondence should be addressed.
Viruses 2023, 15(2), 515; https://doi.org/10.3390/v15020515
Submission received: 21 December 2022 / Revised: 28 January 2023 / Accepted: 8 February 2023 / Published: 13 February 2023
(This article belongs to the Section Animal Viruses)
Browse Figures
Review Reports Versions Notes

Abstract

Chicken anemia virus (CAV) and Gyrovirus homsa 1 (GyH1) are members of the Gyrovirus genus. The two viruses cause similar clinical manifestations in chickens, aplastic anemia and immunosuppression. Our previous investigation displays that CAV and GyH1 often co-infect chickens. However, whether they have synergistic pathogenicity in chickens remains elusive. Here, we established a co-infection model of CAV and GyH1 in specific pathogen-free (SPF) chickens to explore the synergy between CAV and GyH1. We discovered that CAV and GyH1 significantly inhibited weight gain, increased mortality, and hindered erythropoiesis in co-infected chickens. Co-infected chickens exhibited severe immune organ atrophy and lymphocyte exhaustion. The proventriculus and gizzard had severe hemorrhagic necrosis and inflammation. We also discovered that the viral loads and shedding levels were higher and lasted longer in CAV and GyH1 co-infected chickens than in mono-infected chickens. Our results demonstrate that CAV and GyH1 synergistically promote immunosuppression, pathogenicity, and viral replication in co-infected chicken, highlighting the interaction between CAV and GyH1 in the disease process and increasing potential health risk in the poultry breeding industry, and needs further attention.
Keywords: chicken anemia virus (CAV); Gyrovirus homsa 1 (GyH1); synergy; co-infection; immunosuppression; pathogenicity; viral replication chicken anemia virus (CAV); Gyrovirus homsa 1 (GyH1); synergy; co-infection; immunosuppression; pathogenicity; viral replication

Share and Cite

MDPI and ACS Style

Yang, M.; Yang, Q.; Bi, X.; Shi, H.; Yang, J.; Cheng, X.; Yan, T.; Zhang, H.; Cheng, Z. The Synergy of Chicken Anemia Virus and Gyrovirus Homsa 1 in Chickens. Viruses 2023, 15, 515. https://doi.org/10.3390/v15020515

AMA Style

Yang M, Yang Q, Bi X, Shi H, Yang J, Cheng X, Yan T, Zhang H, Cheng Z. The Synergy of Chicken Anemia Virus and Gyrovirus Homsa 1 in Chickens. Viruses. 2023; 15(2):515. https://doi.org/10.3390/v15020515

Chicago/Turabian Style

Yang, Mengzan, Qi Yang, Xiaoqing Bi, Hengyang Shi, Jianhao Yang, Xiangyu Cheng, Tianxing Yan, Honghai Zhang, and Ziqiang Cheng. 2023. "The Synergy of Chicken Anemia Virus and Gyrovirus Homsa 1 in Chickens" Viruses 15, no. 2: 515. https://doi.org/10.3390/v15020515

APA Style

Yang, M., Yang, Q., Bi, X., Shi, H., Yang, J., Cheng, X., Yan, T., Zhang, H., & Cheng, Z. (2023). The Synergy of Chicken Anemia Virus and Gyrovirus Homsa 1 in Chickens. Viruses, 15(2), 515. https://doi.org/10.3390/v15020515

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop