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Article

COVID-19 Severity and Mortality in Two Pandemic Waves in Poland and Predictors of Poor Outcomes of SARS-CoV-2 Infection in Hospitalized Young Adults

1
Department of Otolaryngology, Central Clinical Hospital of the Ministry of Interior and Administration, 02-507 Warsaw, Poland
2
Department of Obstetrics and Gynecology, Central Clinical Hospital of the Ministry of Interior and Administration, 02-507 Warsaw, Poland
3
Department of Plastic Surgery, Central Clinical Hospital of the Ministry of Interior and Administration, 02-507 Warsaw, Poland
4
Center for Reproductive Health, Institute of Mother and Child, 01-211 Warsaw, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Yinzhong Shen
Viruses 2022, 14(8), 1700; https://doi.org/10.3390/v14081700
Received: 7 July 2022 / Revised: 27 July 2022 / Accepted: 28 July 2022 / Published: 31 July 2022
(This article belongs to the Special Issue Risk Factors for COVID-19 Infection)
SARS-CoV-2 variants pose a significant threat to global public health. However, their influence on disease severity, especially among young adults who may exhibit different clinical characteristics, is debatable. In this retrospective study of 229 young adults hospitalized with COVID-19, we investigated the differences between Poland’s second and third waves of the pandemic. To identify potential predictors of severe COVID-19 in young adults, we analyzed patient characteristics and laboratory findings between survivors and non-survivors and we performed logistic regression to assess the risk of death, mechanical ventilation, and intensive care unit treatment. We found no increase in COVID-19 severity comparing the third and second waves of the pandemic, indicating that the alpha variant had no influence on disease severity. In addition, we found that factors, such as obesity, comorbidities, lung involvement, leukocytosis, neutrophilia, lymphopenia, higher IG count, the neutrophil-to-lymphocyte ratio, C-reactive protein, procalcitonin, interleukin-6, D-Dimer, lactate dehydrogenase, high-sensitive troponin I, creatine kinase-myocardial band, myoglobin, N-terminal-pro-B-type natriuretic peptide, creatinine, urea and gamma-glutamyl transferase, lower estimated glomerular filtration rate, albumin, calcium and vitamin D3, possibly a decrease in red blood cell counts, hemoglobin and hematocrit, and an increase in creatine kinase during hospitalization may be associated with poor outcomes of COVID-19. View Full-Text
Keywords: COVID-19; SARS-CoV-2; alpha variant; severity; mortality; predictors; young adults COVID-19; SARS-CoV-2; alpha variant; severity; mortality; predictors; young adults
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MDPI and ACS Style

Ziuzia-Januszewska, L.; Januszewski, M.; Sosnowska-Nowak, J.; Janiszewski, M.; Dobrzyński, P.; Jakimiuk, A.A.; Jakimiuk, A.J. COVID-19 Severity and Mortality in Two Pandemic Waves in Poland and Predictors of Poor Outcomes of SARS-CoV-2 Infection in Hospitalized Young Adults. Viruses 2022, 14, 1700. https://doi.org/10.3390/v14081700

AMA Style

Ziuzia-Januszewska L, Januszewski M, Sosnowska-Nowak J, Janiszewski M, Dobrzyński P, Jakimiuk AA, Jakimiuk AJ. COVID-19 Severity and Mortality in Two Pandemic Waves in Poland and Predictors of Poor Outcomes of SARS-CoV-2 Infection in Hospitalized Young Adults. Viruses. 2022; 14(8):1700. https://doi.org/10.3390/v14081700

Chicago/Turabian Style

Ziuzia-Januszewska, Laura, Marcin Januszewski, Joanna Sosnowska-Nowak, Mariusz Janiszewski, Paweł Dobrzyński, Alicja A. Jakimiuk, and Artur J. Jakimiuk. 2022. "COVID-19 Severity and Mortality in Two Pandemic Waves in Poland and Predictors of Poor Outcomes of SARS-CoV-2 Infection in Hospitalized Young Adults" Viruses 14, no. 8: 1700. https://doi.org/10.3390/v14081700

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