Next Article in Journal / Special Issue
Variant of Concern-Matched COVID-19 Convalescent Plasma Usage in Seronegative Hospitalized Patients
Previous Article in Journal
Diversity of SIRV-like Viruses from a North American Population
Previous Article in Special Issue
Nucleopore Traffic Is Hindered by SARS-CoV-2 ORF6 Protein to Efficiently Suppress IFN-β and IL-6 Secretion
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Viruses
Volume 14
Issue 7
10.3390/v14071441
viruses-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

SARS-CoV-2 Circulation during the First Year of the Pandemic: A Seroprevalence Study from January to December 2020 in Tuscany, Italy

by
Serena Marchi
1,*,
Gianvito Lanave
2,
Michele Camero
2,
Francesca Dapporto
3,
Alessandro Manenti
3,
Linda Benincasa
4,
Angela Acciavatti
5,†,
Giulio Brogi
5,
Simonetta Viviani
1,
Emanuele Montomoli
1,3,4 and
Claudia Maria Trombetta
1
1
Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy
2
Department of Veterinary Medicine, University of Bari, 70010 Valenzano, Italy
3
VisMederi Srl, 53100 Siena, Italy
4
VisMederi Research Srl, 53100 Siena, Italy
5
NeoMedica Srl, 53100 Siena, Italy
*
Author to whom correspondence should be addressed.
†
Deceased.
Viruses 2022, 14(7), 1441; https://doi.org/10.3390/v14071441
Submission received: 21 April 2022 / Revised: 24 June 2022 / Accepted: 28 June 2022 / Published: 30 June 2022
(This article belongs to the Special Issue State-of-the-Art SARS-CoV-2 Research in Italy)
Browse Figures
Versions Notes

Abstract

Italy was the second country affected by the SARS-CoV-2 pandemic; the virus spread mainly in Northern Italy with a subsequent diffusion to the center and southern part of the country. In this study, we aimed to assess the prevalence of antibodies against SARS-CoV-2 in the general population of the Siena province in the Tuscany region (Central Italy) during 2020. A total of 2480 serum samples collected from January to December 2020 were tested for IgM and IgG antibodies against SARS-CoV-2 by a commercial ELISA. Positive and borderline samples were further tested for the presence of anti-receptor-binding domain (RBD) IgM and IgG antibodies by an in-house ELISA and by a micro-neutralization assay. Out of the 2480 samples tested by the commercial ELISA, 81 (3.3%) were found to be positive or borderline for IgG and 58 (2.3%) for IgM in a total of 133 samples (5.4%) found to be positive or borderline for at least one antibody class. When the commercial ELISA and in-house ELISA/micro-neutralization assay results were combined, 26 samples (1.0%) were positive for RBD IgG, 11 (0.4%) for RBD IgM, and 23 (0.9%) for a neutralizing antibody. An increase in seroprevalence was observed during the year 2020, especially from the end of summer, consistent with the routine epidemiological surveillance of COVID-19 cases.
Keywords: SARS-CoV-2; Italy; seroprevalence SARS-CoV-2; Italy; seroprevalence

Share and Cite

MDPI and ACS Style

Marchi, S.; Lanave, G.; Camero, M.; Dapporto, F.; Manenti, A.; Benincasa, L.; Acciavatti, A.; Brogi, G.; Viviani, S.; Montomoli, E.; et al. SARS-CoV-2 Circulation during the First Year of the Pandemic: A Seroprevalence Study from January to December 2020 in Tuscany, Italy. Viruses 2022, 14, 1441. https://doi.org/10.3390/v14071441

AMA Style

Marchi S, Lanave G, Camero M, Dapporto F, Manenti A, Benincasa L, Acciavatti A, Brogi G, Viviani S, Montomoli E, et al. SARS-CoV-2 Circulation during the First Year of the Pandemic: A Seroprevalence Study from January to December 2020 in Tuscany, Italy. Viruses. 2022; 14(7):1441. https://doi.org/10.3390/v14071441

Chicago/Turabian Style

Marchi, Serena, Gianvito Lanave, Michele Camero, Francesca Dapporto, Alessandro Manenti, Linda Benincasa, Angela Acciavatti, Giulio Brogi, Simonetta Viviani, Emanuele Montomoli, and et al. 2022. "SARS-CoV-2 Circulation during the First Year of the Pandemic: A Seroprevalence Study from January to December 2020 in Tuscany, Italy" Viruses 14, no. 7: 1441. https://doi.org/10.3390/v14071441

APA Style

Marchi, S., Lanave, G., Camero, M., Dapporto, F., Manenti, A., Benincasa, L., Acciavatti, A., Brogi, G., Viviani, S., Montomoli, E., & Trombetta, C. M. (2022). SARS-CoV-2 Circulation during the First Year of the Pandemic: A Seroprevalence Study from January to December 2020 in Tuscany, Italy. Viruses, 14(7), 1441. https://doi.org/10.3390/v14071441

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop