Next Article in Journal
Recent Zoonotic Spillover and Tropism Shift of a Canine Coronavirus Is Associated with Relaxed Selection and Putative Loss of Function in NTD Subdomain of Spike Protein
Next Article in Special Issue
SARS-CoV-2 Infection Is Associated with Uncontrolled HIV Viral Load in Non-Hospitalized HIV-Infected Patients from Gugulethu, South Africa
Previous Article in Journal
The E484K Substitution in a SARS-CoV-2 Spike Protein Subunit Vaccine Resulted in Limited Cross-Reactive Neutralizing Antibody Responses in Mice
Previous Article in Special Issue
Persistent Hepatitis B Viraemia with Polymerase Mutations among HIV/HBV Co-Infected Patients on HBV-Active ART in KwaZulu-Natal, South Africa
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Viruses
Volume 14
Issue 5
10.3390/v14050855
viruses-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Complexity of Human Cytomegalovirus Infection in South African HIV-Exposed Infants with Pneumonia

by
Kerusha Govender
1,2,
Raveen Parboosing
1,
Salvatore Camiolo
2,
Petr Hubáček
3,
Irene Görzer
4,
Elisabeth Puchhammer-Stöckl
4 and
Nicolás M. Suárez
2,*
1
Department of Virology, University of KwaZulu Natal and National Health Laboratory Service, Durban 4000, South Africa
2
Medical Research Council-University of Glasgow Centre for Virus Research, Bearsden, Glasgow G61 1QH, UK
3
Department of Medical Microbiology, 2nd Faculty of Medicine, Charles University and Motol University Hospital, 150 06 Prague, Czech Republic
4
Center for Virology, Medical University of Vienna, 1090 Vienna, Austria
*
Author to whom correspondence should be addressed.
Viruses 2022, 14(5), 855; https://doi.org/10.3390/v14050855
Submission received: 18 March 2022 / Revised: 11 April 2022 / Accepted: 19 April 2022 / Published: 21 April 2022
(This article belongs to the Special Issue State-of-the-Art Virology Research in South Africa)
Browse Figure
Review Reports Versions Notes

Abstract

Human cytomegalovirus (HCMV) can cause significant end-organ diseases such as pneumonia in HIV-exposed infants. Complex viral factors may influence pathogenesis including: a large genome with a sizeable coding capacity, numerous gene regions of hypervariability, multiple-strain infections, and tissue compartmentalization of strains. We used a whole genome sequencing approach to assess the complexity of infection by comparing high-throughput sequencing data obtained from respiratory and blood specimens of HIV-exposed infants with severe HCMV pneumonia with those of lung transplant recipients and patients with hematological disorders. There were significantly more specimens from HIV-exposed infants showing multiple HCMV strain infection. Some genotypes, such as UL73 G4B and UL74 G4, were significantly more prevalent in HIV-exposed infants with severe HCMV pneumonia. Some genotypes were predominant in the respiratory specimens of several patients. However, the predominance was not statistically significant, precluding firm conclusions on anatomical compartmentalization in the lung.
Keywords: multiple-strain infections; compartmentalization; human cytomegalovirus; whole genome sequence; HIV; genotype; pneumonia multiple-strain infections; compartmentalization; human cytomegalovirus; whole genome sequence; HIV; genotype; pneumonia

Share and Cite

MDPI and ACS Style

Govender, K.; Parboosing, R.; Camiolo, S.; Hubáček, P.; Görzer, I.; Puchhammer-Stöckl, E.; Suárez, N.M. Complexity of Human Cytomegalovirus Infection in South African HIV-Exposed Infants with Pneumonia. Viruses 2022, 14, 855. https://doi.org/10.3390/v14050855

AMA Style

Govender K, Parboosing R, Camiolo S, Hubáček P, Görzer I, Puchhammer-Stöckl E, Suárez NM. Complexity of Human Cytomegalovirus Infection in South African HIV-Exposed Infants with Pneumonia. Viruses. 2022; 14(5):855. https://doi.org/10.3390/v14050855

Chicago/Turabian Style

Govender, Kerusha, Raveen Parboosing, Salvatore Camiolo, Petr Hubáček, Irene Görzer, Elisabeth Puchhammer-Stöckl, and Nicolás M. Suárez. 2022. "Complexity of Human Cytomegalovirus Infection in South African HIV-Exposed Infants with Pneumonia" Viruses 14, no. 5: 855. https://doi.org/10.3390/v14050855

APA Style

Govender, K., Parboosing, R., Camiolo, S., Hubáček, P., Görzer, I., Puchhammer-Stöckl, E., & Suárez, N. M. (2022). Complexity of Human Cytomegalovirus Infection in South African HIV-Exposed Infants with Pneumonia. Viruses, 14(5), 855. https://doi.org/10.3390/v14050855

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop