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Article

Anti-SARS-CoV-2 Titers Predict the Severity of COVID-19

1
Institute of Microbiology, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland
2
Infectious Diseases Service, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland
3
Intensive Care Unit, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland
4
Service of Internal Medicine, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland
5
Service of Immunology and Allergy, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland
6
ADMED Microbiology, 2300 La Chaux-de-Fonds, Switzerland
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Matthaios Speletas
Viruses 2022, 14(5), 1089; https://doi.org/10.3390/v14051089
Received: 4 April 2022 / Revised: 13 May 2022 / Accepted: 17 May 2022 / Published: 18 May 2022
(This article belongs to the Special Issue Risk Factors for COVID-19 Infection)
Coronavirus disease 2019 (COVID-19) due to SARS-CoV-2 is associated with a wide spectrum of disease, ranging from asymptomatic infection to acute respiratory distress syndrome. Some biomarkers may predict disease severity. Among them, the anti-SARS-CoV-2 antibody response has been related to severe disease. The aim of this study was to assess the correlation between the anti-SARS-CoV-2 serological response and COVID-19 outcome. Demographic, clinical, and biological data from nasopharyngeal-PCR confirmed COVID-19 hospitalized patients were prospectively collected between April and August 2020 at our institution. All patients had serial weekly serology testing for a maximum of three blood samples or until discharge. Two different serological assays were used: a chemiluminescent assay and an in-house developed Luminex immunoassay. Kinetics of the serological response and correlation between the antibody titers and outcome were assessed. Among the 70 patients enrolled in the study, 22 required invasive ventilation, 29 required non-invasive ventilation or oxygen supplementation, and 19 did not require any oxygen supplementation. Median duration of symptoms upon admission for the three groups were 13, 8, and 9 days, respectively. Antibody titers gradually increased for up to 3 weeks since the onset of symptoms for patients requiring oxygen supplementation with significantly higher antibody titers for patients requiring invasive ventilation. Antibody titers on admission were also significantly higher in severely ill patients and serology performed well in predicting the necessity of invasive ventilation (AUC: 0.79, 95% CI: 0.67–0.9). Serology testing at admission may be a good indicator to identify severe COVID-19 patients who will require invasive mechanical ventilation. View Full-Text
Keywords: serology; antibody response; SARS-CoV-2; COVID-19; outcome; disease severity serology; antibody response; SARS-CoV-2; COVID-19; outcome; disease severity
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MDPI and ACS Style

Kritikos, A.; Gabellon, S.; Pagani, J.-L.; Monti, M.; Bochud, P.-Y.; Manuel, O.; Coste, A.; Greub, G.; Perreau, M.; Pantaleo, G.; Croxatto, A.; Lamoth, F. Anti-SARS-CoV-2 Titers Predict the Severity of COVID-19. Viruses 2022, 14, 1089. https://doi.org/10.3390/v14051089

AMA Style

Kritikos A, Gabellon S, Pagani J-L, Monti M, Bochud P-Y, Manuel O, Coste A, Greub G, Perreau M, Pantaleo G, Croxatto A, Lamoth F. Anti-SARS-CoV-2 Titers Predict the Severity of COVID-19. Viruses. 2022; 14(5):1089. https://doi.org/10.3390/v14051089

Chicago/Turabian Style

Kritikos, Antonios, Sophie Gabellon, Jean-Luc Pagani, Matteo Monti, Pierre-Yves Bochud, Oriol Manuel, Alix Coste, Gilbert Greub, Matthieu Perreau, Giuseppe Pantaleo, Antony Croxatto, and Frederic Lamoth. 2022. "Anti-SARS-CoV-2 Titers Predict the Severity of COVID-19" Viruses 14, no. 5: 1089. https://doi.org/10.3390/v14051089

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