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Article

Reversibility of Central Nervous System Adverse Events in Course of Art

by
Lucia Taramasso
1,*,
Giancarlo Orofino
2,
Elena Ricci
3,
Barbara Menzaghi
4,
Giuseppe Vittorio De Socio
5,
Nicola Squillace
6,
Giordano Madeddu
7,
Francesca Vichi
8,
Benedetto Maurizio Celesia
9,
Chiara Molteni
10,
Federico Conti
11,
Filippo Del Puente
12,
Eleonora Sarchi
13,
Goffredo Angioni
14,
Antonio Cascio
15,
Carmela Grosso
16,
Giustino Parruti
17,
Antonio Di Biagio
12 and
Paolo Bonfanti
6 on behalf of CISAI Study Group
1
Infectious Disease Clinic, IRCCS Policlinico San Martino Hospital, 16132 Genoa, Italy
2
Unit of Infectious Diseases, “Divisione A”, Amedeo di Savoia Hospital, 10149 Torino, Italy
3
Fondazione ASIA Onlus, 20090 Buccinasco, Italy
4
Unit of Infectious Diseases, ASST della Valle Olona, Busto Arsizio Hospital, 21052 Busto Arsizio, Italy
5
Clinic of Infectious Diseases, Department of Medicine, Azienda Ospedaliera di Perugia, Santa Maria Hospital, 06129 Perugia, Italy
6
Infectious Diseases Clinic, San Gerardo Hospital, University of Milano-Bicocca, 20126 Monza, Italy
7
Unit of Infectious and Tropical Diseases, Department of Medical, Surgical and Experimental Sciences, University of Sassari, 07100 Sassari, Italy
8
Infectious Diseases Unit 1, Santa Maria Annunziata Hospital, Azienda USL Toscana Centro, 50012 Florence, Italy
9
Unit of Infectious Diseases, University of Catania, ARNAS Garibaldi, 95123 Catania, Italy
10
Infectious Diseases Unit, Ospedale A. Manzoni, 23900 Lecco, Italy
11
Infectious Diseases Unit, Department of Biomedical and Clinical Sciences “Luigi Sacco”, Università Degli Studi di Milano, 20122 Milan, Italy
12
Department of Health Sciences, Infectious Disease Clinic, University of Genoa, 16145 Genoa, Italy
13
Infectious Diseases Unit, SS. Antonio e Biagio e Cesare Arrigo Hospital, 15121 Alessandria, Italy
14
Infectious Diseases Unit, SS Trinità Hospital, 09121 Cagliari, Italy
15
Infectious and Tropical Diseases Unit, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90133 Palermo, Italy
16
Unit of Infectious Diseases, Cesena Hospital, 47521 Cesena, Italy
17
Infectious Diseases Unit, Pescara General Hospital, 66020 Pescara, Italy
 
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*
Author to whom correspondence should be addressed.
Viruses 2022, 14(5), 1028; https://doi.org/10.3390/v14051028
Submission received: 18 March 2022 / Revised: 8 May 2022 / Accepted: 9 May 2022 / Published: 11 May 2022
(This article belongs to the Special Issue Adverse Effects of Antiretroviral Therapy)
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Abstract

The purpose of this study is to evaluate the frequency of central nervous system adverse events (CNS-AE) on dolutegravir (DTG) and non-DTG containing ART, and their reversibility, in the observational prospective SCOLTA cohort. Factors associated with CNS-AE were estimated using a Cox proportional-hazards model. 4939 people living with HIV (PLWH) were enrolled in DTG (n = 1179) and non-DTG (n = 3760) cohorts. Sixty-six SNC-AE leading to ART discontinuation were reported, 39/1179 (3.3%) in DTG and 27/3760 (0.7%) in non-DTG cohort. PLWH naïve to ART, with higher CD4 + T count and with psychiatric disorders were more likely to develop a CNS-AE. The risk was lower in non-DTG than DTG-cohort (aHR 0.33, 95% CI 0.19–0.55, p < 0.0001). One-year follow-up was available for 63/66 PLWH with CNS-AE. AE resolution was reported in 35/39 and 23/24 cases in DTG and non-DTG cohorts, respectively. The probability of AE reversibility was not different based on ART class, sex, ethnicity, CDC stage, or baseline psychiatric disorder. At the same time, a lower rate of event resolution was found in PLWH older than 50 years (p = 0.017). In conclusion, CNS-AE leading to ART discontinuation was more frequent in DTG than non-DTG treated PLWH. Most CNS-AE resolved after ART switch, similarly in both DTG and non-DTG cohorts.
Keywords: CNS; adverse events; HIV; dolutegravir; reversibility; neurocognitive; psychiatric CNS; adverse events; HIV; dolutegravir; reversibility; neurocognitive; psychiatric

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MDPI and ACS Style

Taramasso, L.; Orofino, G.; Ricci, E.; Menzaghi, B.; De Socio, G.V.; Squillace, N.; Madeddu, G.; Vichi, F.; Celesia, B.M.; Molteni, C.; et al. Reversibility of Central Nervous System Adverse Events in Course of Art. Viruses 2022, 14, 1028. https://doi.org/10.3390/v14051028

AMA Style

Taramasso L, Orofino G, Ricci E, Menzaghi B, De Socio GV, Squillace N, Madeddu G, Vichi F, Celesia BM, Molteni C, et al. Reversibility of Central Nervous System Adverse Events in Course of Art. Viruses. 2022; 14(5):1028. https://doi.org/10.3390/v14051028

Chicago/Turabian Style

Taramasso, Lucia, Giancarlo Orofino, Elena Ricci, Barbara Menzaghi, Giuseppe Vittorio De Socio, Nicola Squillace, Giordano Madeddu, Francesca Vichi, Benedetto Maurizio Celesia, Chiara Molteni, and et al. 2022. "Reversibility of Central Nervous System Adverse Events in Course of Art" Viruses 14, no. 5: 1028. https://doi.org/10.3390/v14051028

APA Style

Taramasso, L., Orofino, G., Ricci, E., Menzaghi, B., De Socio, G. V., Squillace, N., Madeddu, G., Vichi, F., Celesia, B. M., Molteni, C., Conti, F., Del Puente, F., Sarchi, E., Angioni, G., Cascio, A., Grosso, C., Parruti, G., Di Biagio, A., & Bonfanti, P., on behalf of CISAI Study Group. (2022). Reversibility of Central Nervous System Adverse Events in Course of Art. Viruses, 14(5), 1028. https://doi.org/10.3390/v14051028

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