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Structural Bases of Zoonotic and Zooanthroponotic Transmission of SARS-CoV-2

Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster LA1 4YG, UK
Author to whom correspondence should be addressed.
Academic Editors: Giulietta Venturi, Claudia Fortuna and Marco Di Luca
Viruses 2022, 14(2), 418;
Received: 12 December 2021 / Revised: 25 January 2022 / Accepted: 7 February 2022 / Published: 17 February 2022
(This article belongs to the Special Issue Emerging Zoonotic Viral Diseases)
The emergence of multiple variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) highlights the importance of possible animal-to-human (zoonotic) and human-to-animal (zooanthroponotic) transmission and potential spread within animal species. A range of animal species have been verified for SARS-CoV-2 susceptibility, either in vitro or in vivo. However, the molecular bases of such a broad host spectrum for the SARS-CoV-2 remains elusive. Here, we structurally and genetically analysed the interaction between the spike protein, with a particular focus on receptor binding domains (RBDs), of SARS-CoV-2 and its receptor angiotensin-converting enzyme 2 (ACE2) for all conceivably susceptible groups of animals to gauge the structural bases of the SARS-CoV-2 host spectrum. We describe our findings in the context of existing animal infection-based models to provide a foundation on the possible virus persistence in animals and their implications in the future eradication of COVID-19. View Full-Text
Keywords: SARS-CoV-2; zoonotic; transmission; ACE2; eradication SARS-CoV-2; zoonotic; transmission; ACE2; eradication
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MDPI and ACS Style

Clayton, E.; Ackerley, J.; Aelmans, M.; Ali, N.; Ashcroft, Z.; Ashton, C.; Barker, R.; Budryte, V.; Burrows, C.; Cai, S.; Callaghan, A.; Carberry, J.; Chatwin, R.; Davies, I.; Farlow, C.; Gamblin, S.; Iacobut, A.; Lambe, A.; Lynch, F.; Mihalache, D.; Mokbel, A.; Potamsetty, S.; Qadir, Z.; Soden, J.; Sun, X.; Vasile, A.; Wheeler, O.; Rohaim, M.A.; Munir, M. Structural Bases of Zoonotic and Zooanthroponotic Transmission of SARS-CoV-2. Viruses 2022, 14, 418.

AMA Style

Clayton E, Ackerley J, Aelmans M, Ali N, Ashcroft Z, Ashton C, Barker R, Budryte V, Burrows C, Cai S, Callaghan A, Carberry J, Chatwin R, Davies I, Farlow C, Gamblin S, Iacobut A, Lambe A, Lynch F, Mihalache D, Mokbel A, Potamsetty S, Qadir Z, Soden J, Sun X, Vasile A, Wheeler O, Rohaim MA, Munir M. Structural Bases of Zoonotic and Zooanthroponotic Transmission of SARS-CoV-2. Viruses. 2022; 14(2):418.

Chicago/Turabian Style

Clayton, Emily, Jacob Ackerley, Marianne Aelmans, Noor Ali, Zoe Ashcroft, Clara Ashton, Robert Barker, Vakare Budryte, Callum Burrows, Shanshan Cai, Alex Callaghan, Jake Carberry, Rebecca Chatwin, Isabella Davies, Chloe Farlow, Samuel Gamblin, Aida Iacobut, Adam Lambe, Francesca Lynch, Diana Mihalache, Amani Mokbel, Santosh Potamsetty, Zara Qadir, Jack Soden, Xiaohan Sun, Alexandru Vasile, Otto Wheeler, Mohammed A. Rohaim, and Muhammad Munir. 2022. "Structural Bases of Zoonotic and Zooanthroponotic Transmission of SARS-CoV-2" Viruses 14, no. 2: 418.

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