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Mammals Preferred: Reassortment of Batai and Bunyamwera orthobunyavirus Occurs in Mammalian but Not Insect Cells

1
Department of Arbovirology, Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany
2
Institute for Parasitology, Center for Infection Medicine, University of Veterinary Medicine Hannover, 30559 Hanover, Germany
3
Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, 30559 Hanover, Germany
4
Institute of Infectology, Friedrich-Loeffler-Institute, Federal Research Institute for Animal Health, Südufer 10, 17493 Greifswald, Germany
5
Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hanover, Germany
6
Faculty of Mathematics, Informatics and Natural Sciences, University of Hamburg, 20148 Hamburg, Germany
7
Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, 30559 Hanover, Germany
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Nikos Vasilakis
Viruses 2021, 13(9), 1702; https://doi.org/10.3390/v13091702
Received: 9 July 2021 / Revised: 17 August 2021 / Accepted: 21 August 2021 / Published: 27 August 2021
(This article belongs to the Special Issue Bunyavirus 2020)
Reassortment is a viral genome-segment recomposition known for many viruses, including the orthobunyaviruses. The co-infection of a host cell with two viruses of the same serogroup, such as the Bunyamwera orthobunyavirus and the Batai orthobunyavirus, can give rise to novel viruses. One example is the Ngari virus, which has caused major outbreaks of human infections in Central Africa. This study aimed to investigate the potential for reassortment of Bunyamwera orthobunyavirus and the Batai orthobunyavirus during co-infection studies and the replication properties of the reassortants in different mammalian and insect cell lines. In the co-infection studies, a Ngari-like virus reassortant and a novel reassortant virus, the Batunya virus, arose in BHK-21 cells (Mesocricetus auratus). In contrast, no reassortment was observed in the examined insect cells from Aedes aegypti (Aag2) and Aedes albopictus (U4.4 and C6/36). The growth kinetic experiments show that both reassortants are replicated to higher titers in some mammalian cell lines than the parental viruses but show impaired growth in insect cell lines. View Full-Text
Keywords: viral reassortment; orthobunyaviruses; insect cells viral reassortment; orthobunyaviruses; insect cells
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MDPI and ACS Style

Heitmann, A.; Gusmag, F.; Rathjens, M.G.; Maurer, M.; Frankze, K.; Schicht, S.; Jansen, S.; Schmidt-Chanasit, J.; Jung, K.; Becker, S.C. Mammals Preferred: Reassortment of Batai and Bunyamwera orthobunyavirus Occurs in Mammalian but Not Insect Cells. Viruses 2021, 13, 1702. https://doi.org/10.3390/v13091702

AMA Style

Heitmann A, Gusmag F, Rathjens MG, Maurer M, Frankze K, Schicht S, Jansen S, Schmidt-Chanasit J, Jung K, Becker SC. Mammals Preferred: Reassortment of Batai and Bunyamwera orthobunyavirus Occurs in Mammalian but Not Insect Cells. Viruses. 2021; 13(9):1702. https://doi.org/10.3390/v13091702

Chicago/Turabian Style

Heitmann, Anna, Frederic Gusmag, Martin G. Rathjens, Maurice Maurer, Kati Frankze, Sabine Schicht, Stephanie Jansen, Jonas Schmidt-Chanasit, Klaus Jung, and Stefanie C. Becker. 2021. "Mammals Preferred: Reassortment of Batai and Bunyamwera orthobunyavirus Occurs in Mammalian but Not Insect Cells" Viruses 13, no. 9: 1702. https://doi.org/10.3390/v13091702

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