Targeting Viral Surface Proteins through Structure-Based Design

Narkhede, Yogesh B; Gonzalez, Karen J; Strauch, Eva-Maria

doi:10.3390/v13071320

Open AccessReview

Targeting Viral Surface Proteins through Structure-Based Design

by

Yogesh B Narkhede

^1,†

,

Karen J Gonzalez

^2,†

and

Eva-Maria Strauch

^1,2,*

¹

Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, GA 30602, USA

²

Institute of Bioinformatics, University of Georgia, Athens, GA 30602, USA

^*

Author to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Viruses 2021, 13(7), 1320; https://doi.org/10.3390/v13071320

Submission received: 5 June 2021 / Revised: 30 June 2021 / Accepted: 1 July 2021 / Published: 8 July 2021

(This article belongs to the Special Issue Novel Vaccines and Drugs That Target the Surface Glycoproteins of Respiratory Viruses)

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Abstract

The emergence of novel viral infections of zoonotic origin and mutations of existing human pathogenic viruses represent a serious concern for public health. It warrants the establishment of better interventions and protective therapies to combat the virus and prevent its spread. Surface glycoproteins catalyzing the fusion of viral particles and host cells have proven to be an excellent target for antivirals as well as vaccines. This review focuses on recent advances for computational structure-based design of antivirals and vaccines targeting viral fusion machinery to control seasonal and emerging respiratory viruses.

Keywords: vaccine; glycoproteins; structural vaccinology; rational design; computational protein design; respiratory viruses

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MDPI and ACS Style

Narkhede, Y.B.; Gonzalez, K.J.; Strauch, E.-M. Targeting Viral Surface Proteins through Structure-Based Design. Viruses 2021, 13, 1320. https://doi.org/10.3390/v13071320

AMA Style

Narkhede YB, Gonzalez KJ, Strauch E-M. Targeting Viral Surface Proteins through Structure-Based Design. Viruses. 2021; 13(7):1320. https://doi.org/10.3390/v13071320

Chicago/Turabian Style

Narkhede, Yogesh B, Karen J Gonzalez, and Eva-Maria Strauch. 2021. "Targeting Viral Surface Proteins through Structure-Based Design" Viruses 13, no. 7: 1320. https://doi.org/10.3390/v13071320

APA Style

Narkhede, Y. B., Gonzalez, K. J., & Strauch, E.-M. (2021). Targeting Viral Surface Proteins through Structure-Based Design. Viruses, 13(7), 1320. https://doi.org/10.3390/v13071320

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Targeting Viral Surface Proteins through Structure-Based Design

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