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Hepatitis D Virus and Hepatocellular Carcinoma

HDV-Like Viruses

CIRI—Centre International de Recherche en Infectiologie, Université de Lyon, Université Claude Bernard Lyon 1, Inserm, U1111, CNRS, UMR5308, ENS Lyon, 46 allée d’Italie, F-69007 Lyon, France
LBBE UMR5558 CNRS—Centre National de la Recherche Scientifique, Université de Lyon 1—48 bd du 11 Novembre 1918, 69100 Villeurbanne, France
Author to whom correspondence should be addressed.
Academic Editor: Stefan Urban
Viruses 2021, 13(7), 1207;
Received: 5 May 2021 / Revised: 11 June 2021 / Accepted: 16 June 2021 / Published: 23 June 2021
(This article belongs to the Special Issue Hepatitis Delta Virus)
Hepatitis delta virus (HDV) is a defective human virus that lacks the ability to produce its own envelope proteins and is thus dependent on the presence of a helper virus, which provides its surface proteins to produce infectious particles. Hepatitis B virus (HBV) was so far thought to be the only helper virus described to be associated with HDV. However, recent studies showed that divergent HDV-like viruses could be detected in fishes, birds, amphibians, and invertebrates, without evidence of any HBV-like agent supporting infection. Another recent study demonstrated that HDV can be transmitted and propagated in experimental infections ex vivo and in vivo by different enveloped viruses unrelated to HBV, including hepatitis C virus (HCV) and flaviviruses such as Dengue and West Nile virus. All this new evidence, in addition to the identification of novel virus species within a large range of hosts in absence of HBV, suggests that deltaviruses may take advantage of a large spectrum of helper viruses and raises questions about HDV origins and evolution. View Full-Text
Keywords: HDV-like viruses; helper virus; origin; evolution HDV-like viruses; helper virus; origin; evolution
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MDPI and ACS Style

Pérez-Vargas, J.; Pereira de Oliveira, R.; Jacquet, S.; Pontier, D.; Cosset, F.-L.; Freitas, N. HDV-Like Viruses. Viruses 2021, 13, 1207.

AMA Style

Pérez-Vargas J, Pereira de Oliveira R, Jacquet S, Pontier D, Cosset F-L, Freitas N. HDV-Like Viruses. Viruses. 2021; 13(7):1207.

Chicago/Turabian Style

Pérez-Vargas, Jimena, Rémi Pereira de Oliveira, Stéphanie Jacquet, Dominique Pontier, François-Loïc Cosset, and Natalia Freitas. 2021. "HDV-Like Viruses" Viruses 13, no. 7: 1207.

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