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Review

Harnessing the Natural Biology of Adeno-Associated Virus to Enhance the Efficacy of Cancer Gene Therapy

1
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA
2
Department of Ophthalmology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
3
Gene Therapy Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
*
Authors to whom correspondence should be addressed.
Academic Editors: Carla Varanda and Patrick Materatski
Viruses 2021, 13(7), 1205; https://doi.org/10.3390/v13071205
Received: 3 May 2021 / Revised: 8 June 2021 / Accepted: 10 June 2021 / Published: 23 June 2021
(This article belongs to the Special Issue The Application of Viruses to Biotechnology)
Adeno-associated virus (AAV) was first characterized as small “defective” contaminant particles in a simian adenovirus preparation in 1965. Since then, a recombinant platform of AAV (rAAV) has become one of the leading candidates for gene therapy applications resulting in two FDA-approved treatments for rare monogenic diseases and many more currently in various phases of the pharmaceutical development pipeline. Herein, we summarize rAAV approaches for the treatment of diverse types of cancers and highlight the natural anti-oncogenic effects of wild-type AAV (wtAAV), including interactions with the cellular host machinery, that are of relevance to enhance current treatment strategies for cancer. View Full-Text
Keywords: adeno-associated virus; AAV; cancer gene therapy adeno-associated virus; AAV; cancer gene therapy
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MDPI and ACS Style

Bower, J.J.; Song, L.; Bastola, P.; Hirsch, M.L. Harnessing the Natural Biology of Adeno-Associated Virus to Enhance the Efficacy of Cancer Gene Therapy. Viruses 2021, 13, 1205. https://doi.org/10.3390/v13071205

AMA Style

Bower JJ, Song L, Bastola P, Hirsch ML. Harnessing the Natural Biology of Adeno-Associated Virus to Enhance the Efficacy of Cancer Gene Therapy. Viruses. 2021; 13(7):1205. https://doi.org/10.3390/v13071205

Chicago/Turabian Style

Bower, Jacquelyn J., Liujiang Song, Prabhakar Bastola, and Matthew L. Hirsch 2021. "Harnessing the Natural Biology of Adeno-Associated Virus to Enhance the Efficacy of Cancer Gene Therapy" Viruses 13, no. 7: 1205. https://doi.org/10.3390/v13071205

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