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Article

Age and Infectious Dose Significantly Affect Disease Progression after RHDV2 Infection in Naïve Domestic Rabbits

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Health & Biosecurity, Commonwealth Scientific and Industrial Research Organisation, Acton, ACT 2601, Australia
2
Centre for Invasive Species Solutions, Bruce, ACT 2617, Australia
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NSW Department of Primary Industries, Elizabeth Macarthur Agricultural Institute, Menangle, NSW 2568, Australia
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Wildlife Ecology and Management, Manaaki Whenua-Landcare Research, Lincoln 7608, New Zealand
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Agriculture & Food, Commonwealth Scientific and Industrial Research Organisation, Acton, ACT 2601, Australia
*
Author to whom correspondence should be addressed.
Academic Editor: John S. L. Parker
Viruses 2021, 13(6), 1184; https://doi.org/10.3390/v13061184
Received: 17 May 2021 / Revised: 18 June 2021 / Accepted: 19 June 2021 / Published: 21 June 2021
(This article belongs to the Section Animal Viruses)
Rabbit haemorrhagic disease virus 2 (RHDV2 or GI.2, referring to any virus with lagovirus GI.2 structural genes) is a recently emerged calicivirus that causes generalised hepatic necrosis and disseminated intravascular coagulation leading to death in susceptible lagomorphs (rabbits and hares). Previous studies investigating the virulence of RHDV2 have reported conflicting results, with case fatality rates ranging from 0% to 100% even within a single study. Lagoviruses are of particular importance in Australia and New Zealand where they are used as biocontrol agents to manage wild rabbit populations, which threaten over 300 native species and result in economic impacts in excess of $200 million AUD annually to Australian agricultural industries. It is critically important that any pest control method is both highly effective (i.e., virulent, in the context of viral biocontrols) and has minimal animal welfare impacts. To determine whether RHDV2 might be a suitable candidate biocontrol agent, we investigated the virulence and disease progression of a naturally occurring Australian recombinant RHDV2 in both 5-week-old and 11-week-old New Zealand White laboratory rabbits after either high or low dose oral infection. Objective measures of disease progression were recorded through continuous body temperature monitoring collars, continuous activity monitors, and twice daily observations. We observed a 100% case fatality rate in both infected kittens and adult rabbits after either high dose or low dose infection. Clinical signs of disease, such as pyrexia, weight loss, and reduced activity, were evident in the late stages of infection. Clinical disease, i.e., welfare impacts, were limited to the period after the onset of pyrexia, lasting on average 12 h and increasing in severity as disease progressed. These findings confirm the high virulence of this RHDV2 variant in naïve rabbits. While age and infectious dose significantly affected disease progression, the case fatality rate was consistently 100% under all conditions tested. View Full-Text
Keywords: rabbit haemorrhagic disease virus; lagovirus; virulence; calicivirus; RHDV2; animal welfare; rabbit rabbit haemorrhagic disease virus; lagovirus; virulence; calicivirus; RHDV2; animal welfare; rabbit
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MDPI and ACS Style

Hall, R.N.; King, T.; O'Connor, T.; Read, A.J.; Arrow, J.; Trought, K.; Duckworth, J.; Piper, M.; Strive, T. Age and Infectious Dose Significantly Affect Disease Progression after RHDV2 Infection in Naïve Domestic Rabbits. Viruses 2021, 13, 1184. https://doi.org/10.3390/v13061184

AMA Style

Hall RN, King T, O'Connor T, Read AJ, Arrow J, Trought K, Duckworth J, Piper M, Strive T. Age and Infectious Dose Significantly Affect Disease Progression after RHDV2 Infection in Naïve Domestic Rabbits. Viruses. 2021; 13(6):1184. https://doi.org/10.3390/v13061184

Chicago/Turabian Style

Hall, Robyn N., Tegan King, Tiffany O'Connor, Andrew J. Read, Jane Arrow, Katherine Trought, Janine Duckworth, Melissa Piper, and Tanja Strive. 2021. "Age and Infectious Dose Significantly Affect Disease Progression after RHDV2 Infection in Naïve Domestic Rabbits" Viruses 13, no. 6: 1184. https://doi.org/10.3390/v13061184

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