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Article

Neutralising Antibodies against Enterovirus and Parechovirus in IVIG Reflect General Circulation: A Tool for Sero-Surveillance

1
Department of Medical Microbiology Microvida, Elisabeth-Tweesteden Ziekenhuis, 5022 GC Tilburg, The Netherlands
2
Department of Medical Microbiology, Amsterdam University Medical Centres, Locatie AMC, 1105 AZ Amsterdam, The Netherlands
3
Emma Children’s Hospital, Department of Pediatric Infectious Diseases, Amsterdam University Medical Centres, Location AMC, 1105 AZ Amsterdam, The Netherlands
*
Author to whom correspondence should be addressed.
Academic Editors: Javier Martin and Erwin Duizer
Viruses 2021, 13(6), 1028; https://doi.org/10.3390/v13061028
Received: 23 April 2021 / Revised: 17 May 2021 / Accepted: 25 May 2021 / Published: 29 May 2021
(This article belongs to the Special Issue Surveillance for Polio and Non-polio Enteroviruses)
Non-polio enteroviruses (NPEV) and parechoviruses (PeV) are widespread pathogens that cause significant morbidity. Surveillance is based on culturing or genotyping of virus strains found in clinical samples. Sero-surveillance, by measuring neutralising antibodies (nAb) through virus neutralisation assays (VNA), could provide additional information as it offers a more comprehensive overview of exposure to circulating types in the general population. In our study we evaluated Intravenous immunoglobulins (IVIG) to generate sero-surveillance data. We performed VNA of nineteen NPEV and PeV with Dutch IVIG batches from two different time points (2010 and 2017) and an IVIG batch from Vietnam (2011). We compared our findings with geno- and sero-surveillance data and evaluated changes over time and between the two countries. Our findings show a good correlation with what is known from geno-surveillance data. The highest nAb titres were found against strains from Enterovirus B, while we did not observe nAb titres against strains belonging to Enterovirus C. In conclusion, we demonstrated that sero-surveillance by means of IVIG can be used to obtain insight into circulation of EV and PeV genotypes. This is of particular interest for public health, to evaluate changes over time and population susceptibility to emerging genotypes. View Full-Text
Keywords: Enterovirus; Parechovirus; surveillance; sero-surveillance; virus neutralisation assay Enterovirus; Parechovirus; surveillance; sero-surveillance; virus neutralisation assay
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MDPI and ACS Style

Couderé, K.; van der Straten, K.; Brouwer, L.; Koen, G.; van Eijk, H.; Pajkrt, D.; Murk, J.-L.; Wolthers, K.C. Neutralising Antibodies against Enterovirus and Parechovirus in IVIG Reflect General Circulation: A Tool for Sero-Surveillance. Viruses 2021, 13, 1028. https://doi.org/10.3390/v13061028

AMA Style

Couderé K, van der Straten K, Brouwer L, Koen G, van Eijk H, Pajkrt D, Murk J-L, Wolthers KC. Neutralising Antibodies against Enterovirus and Parechovirus in IVIG Reflect General Circulation: A Tool for Sero-Surveillance. Viruses. 2021; 13(6):1028. https://doi.org/10.3390/v13061028

Chicago/Turabian Style

Couderé, Karen, Karlijn van der Straten, Lieke Brouwer, Gerrit Koen, Hetty van Eijk, Dasja Pajkrt, Jean-Luc Murk, and Katja C. Wolthers. 2021. "Neutralising Antibodies against Enterovirus and Parechovirus in IVIG Reflect General Circulation: A Tool for Sero-Surveillance" Viruses 13, no. 6: 1028. https://doi.org/10.3390/v13061028

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