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Article

Prevalence of Neutralizing Antibodies to Canine Distemper Virus and Response to Vaccination in Client-Owned Adult Healthy Dogs

1
Clinic of Small Animal Medicine, LMU Munich, Veterinaerstrasse 13, 80539 Munich, Germany
2
Institute of Animal Hygiene and Veterinary Public Health, University of Leipzig, An den Tierkliniken 1, 04103 Leipzig, Germany
*
Author to whom correspondence should be addressed.
Academic Editors: Margaret Hosie and Regina Hofmann-Lehmann
Viruses 2021, 13(5), 945; https://doi.org/10.3390/v13050945
Received: 11 March 2021 / Revised: 11 May 2021 / Accepted: 17 May 2021 / Published: 20 May 2021
(This article belongs to the Special Issue Viral Infections in Companion Animals)
Re-vaccinations against canine distemper virus (CDV) are commonly performed in 3-year intervals. The study’s aims were to determine anti-CDV antibodies in healthy adult dogs within 28 days of vaccination against CDV, and to evaluate factors associated with the presence of pre-vaccination antibodies and with the antibody response to vaccination. Ninety-seven dogs, not vaccinated within 1 year before enrollment, were vaccinated with a modified live CDV vaccine. A measurement of the antibodies was performed before vaccination (day 0), on day 7, and 28 after the vaccination by virus neutralization. A response to vaccination was defined as a ≥4-fold titer increase by day 28. Fisher’s exact test was used to determine factors associated with a lack of antibodies and vaccination response. In total, 94.8% of the dogs (92/97; CI 95%: 88.2–98.1) had antibodies (≥10) prior to vaccination. A response to vaccination was not observed in any dog. Five dogs were considered humoral non-responders; these dogs neither had detectable antibodies before, nor developed antibodies after vaccination. Young age (<2 years) was significantly associated with a lack of pre-vaccination antibodies (p = 0.018; OR: 26.825; 95% CI: 1.216–1763.417). In conclusion, necessity of re-vaccination in adult healthy dogs should be debated and regular vaccinations should be replaced by antibody detection. View Full-Text
Keywords: CDV; vaccine; antibody titer; virus neutralization; protection CDV; vaccine; antibody titer; virus neutralization; protection
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MDPI and ACS Style

Bergmann, M.; Freisl, M.; Zablotski, Y.; Khan, M.A.A.; Speck, S.; Truyen, U.; Hartmann, K. Prevalence of Neutralizing Antibodies to Canine Distemper Virus and Response to Vaccination in Client-Owned Adult Healthy Dogs. Viruses 2021, 13, 945. https://doi.org/10.3390/v13050945

AMA Style

Bergmann M, Freisl M, Zablotski Y, Khan MAA, Speck S, Truyen U, Hartmann K. Prevalence of Neutralizing Antibodies to Canine Distemper Virus and Response to Vaccination in Client-Owned Adult Healthy Dogs. Viruses. 2021; 13(5):945. https://doi.org/10.3390/v13050945

Chicago/Turabian Style

Bergmann, Michèle, Monika Freisl, Yury Zablotski, Md A.A. Khan, Stephanie Speck, Uwe Truyen, and Katrin Hartmann. 2021. "Prevalence of Neutralizing Antibodies to Canine Distemper Virus and Response to Vaccination in Client-Owned Adult Healthy Dogs" Viruses 13, no. 5: 945. https://doi.org/10.3390/v13050945

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