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Article

SARS-CoV-2 Infections and Viral Isolations among Serially Tested Cats and Dogs in Households with Infected Owners in Texas, USA

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College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA
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Laboratory of Respiratory Viruses and Measles, SARS-CoV-2 National Reference Laboratory and Regional Reference Laboratory in the Americas (PAHO/WHO), Fiocruz, Rio de Janeiro 21040-360, Brazil
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Department of Entomology, Texas A&M University and AgriLife Research, College Station, TX 77843, USA
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National Veterinary Services Laboratories, USDA APHIS VS, Ames, IA 50010, USA
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Brazos County Health Department, Bryan, TX 77803, USA
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National Center for Emerging and Zoonotic Infectious Diseases, U.S. Centers for Disease Control and Prevention, Atlanta, GA 30329, USA
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School of Public Health, Texas A&M University, College Station, TX 77843, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Margaret Hosie and Regina Hofmann-Lehmann
Viruses 2021, 13(5), 938; https://doi.org/10.3390/v13050938
Received: 16 April 2021 / Revised: 12 May 2021 / Accepted: 15 May 2021 / Published: 19 May 2021
(This article belongs to the Special Issue Viral Infections in Companion Animals)
Understanding the ecological and epidemiological roles of pets in the transmission of SARS-CoV-2 is critical for animal and human health, identifying household reservoirs, and predicting the potential enzootic maintenance of the virus. We conducted a longitudinal household transmission study of 76 dogs and cats living with at least one SARS-CoV-2-infected human in Texas and found that 17 pets from 25.6% of 39 households met the national case definition for SARS-CoV-2 infections in animals. This includes three out of seventeen (17.6%) cats and one out of fifty-nine (1.7%) dogs that were positive by RT-PCR and sequencing, with the virus successfully isolated from the respiratory swabs of one cat and one dog. Whole-genome sequences of SARS-CoV-2 obtained from all four PCR-positive animals were unique variants grouping with genomes circulating among people with COVID-19 in Texas. Re-sampling showed persistence of viral RNA for at least 25 d-post initial test. Additionally, seven out of sixteen (43.8%) cats and seven out of fifty-nine (11.9%) dogs harbored SARS-CoV-2 neutralizing antibodies upon initial sampling, with relatively stable or increasing titers over the 2–3 months of follow-up and no evidence of seroreversion. The majority (82.4%) of infected pets were asymptomatic. ‘Reverse zoonotic’ transmission of SARS-CoV-2 from infected people to animals may occur more frequently than recognized. View Full-Text
Keywords: SARS-CoV-2; cats; dogs; reverse zoonosis; virus isolation; neutralizing antibodies SARS-CoV-2; cats; dogs; reverse zoonosis; virus isolation; neutralizing antibodies
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MDPI and ACS Style

Hamer, S.A.; Pauvolid-Corrêa, A.; Zecca, I.B.; Davila, E.; Auckland, L.D.; Roundy, C.M.; Tang, W.; Torchetti, M.K.; Killian, M.L.; Jenkins-Moore, M.; Mozingo, K.; Akpalu, Y.; Ghai, R.R.; Spengler, J.R.; Barton Behravesh, C.; Fischer, R.S.B.; Hamer, G.L. SARS-CoV-2 Infections and Viral Isolations among Serially Tested Cats and Dogs in Households with Infected Owners in Texas, USA. Viruses 2021, 13, 938. https://doi.org/10.3390/v13050938

AMA Style

Hamer SA, Pauvolid-Corrêa A, Zecca IB, Davila E, Auckland LD, Roundy CM, Tang W, Torchetti MK, Killian ML, Jenkins-Moore M, Mozingo K, Akpalu Y, Ghai RR, Spengler JR, Barton Behravesh C, Fischer RSB, Hamer GL. SARS-CoV-2 Infections and Viral Isolations among Serially Tested Cats and Dogs in Households with Infected Owners in Texas, USA. Viruses. 2021; 13(5):938. https://doi.org/10.3390/v13050938

Chicago/Turabian Style

Hamer, Sarah A., Alex Pauvolid-Corrêa, Italo B. Zecca, Edward Davila, Lisa D. Auckland, Christopher M. Roundy, Wendy Tang, Mia K. Torchetti, Mary L. Killian, Melinda Jenkins-Moore, Katie Mozingo, Yao Akpalu, Ria R. Ghai, Jessica R. Spengler, Casey Barton Behravesh, Rebecca S.B. Fischer, and Gabriel L. Hamer. 2021. "SARS-CoV-2 Infections and Viral Isolations among Serially Tested Cats and Dogs in Households with Infected Owners in Texas, USA" Viruses 13, no. 5: 938. https://doi.org/10.3390/v13050938

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