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Review

The Role of Non-Structural Protein NSs in the Pathogenesis of Severe Fever with Thrombocytopenia Syndrome

by 1,2, 1,3 and 1,2,*
1
Laboratory of Virus Immunology, Institute for Frontier Life and Medical Science, Kyoto University, Kyoto 606-8507, Japan
2
Laboratory of Molecular and Cellular Immunology, Graduate School of Biostudies, Kyoto University, Kyoto 606-8507, Japan
3
Institute of Cardiovascular Immunology, University Hospital Bonn, University of Bonn, 53127 Bonn, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Masayuki Saijo
Viruses 2021, 13(5), 876; https://doi.org/10.3390/v13050876
Received: 15 April 2021 / Revised: 5 May 2021 / Accepted: 6 May 2021 / Published: 11 May 2021
(This article belongs to the Special Issue Severe Fever with Thrombocytopenia Syndrome Virus)
Viral non-structural proteins, such as NSs of the newly emerging severe fever with thrombocytopenia syndrome virus, are well established virulence factors, mediating viral pathogenesis and disease progression through various mechanisms. NSs has been described as a potent interferon antagonist and NF-κB agonist, two divergent signaling pathways in many immune responses upon a viral encounter. In this review, we highlight the many mechanisms used by NSs on the host that promote viral replication and hyper-inflammation. Understanding these host-pathogen interactions is crucial for antiviral therapy development. View Full-Text
Keywords: SFTSV NSs; NF-κB; cytokine storm; TBK1; viral pathogenesis; interferons; innate immunity SFTSV NSs; NF-κB; cytokine storm; TBK1; viral pathogenesis; interferons; innate immunity
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MDPI and ACS Style

Khalil, J.; Kato, H.; Fujita, T. The Role of Non-Structural Protein NSs in the Pathogenesis of Severe Fever with Thrombocytopenia Syndrome. Viruses 2021, 13, 876. https://doi.org/10.3390/v13050876

AMA Style

Khalil J, Kato H, Fujita T. The Role of Non-Structural Protein NSs in the Pathogenesis of Severe Fever with Thrombocytopenia Syndrome. Viruses. 2021; 13(5):876. https://doi.org/10.3390/v13050876

Chicago/Turabian Style

Khalil, Jumana, Hiroki Kato, and Takashi Fujita. 2021. "The Role of Non-Structural Protein NSs in the Pathogenesis of Severe Fever with Thrombocytopenia Syndrome" Viruses 13, no. 5: 876. https://doi.org/10.3390/v13050876

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