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Review

Pathogenic Role of Epstein–Barr Virus in Lung Cancers

1
Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
2
National Research Center for the Control and Prevention of Infectious Diseases, Nagasaki University, Sakamoto, Nagasaki 852-8523, Japan
3
Department of Pathology and Laboratory Medicine, Tulane University Health Sciences Center and Tulane Cancer Center, New Orleans, LA 70112, USA
4
Institute of Translational Research, Ochsner Clinic Foundation, New Orleans, LA 70121, USA
*
Author to whom correspondence should be addressed.
These authors have contributed equally to this work.
Academic Editors: Sylvain Latour and Benjamin Gewurz
Viruses 2021, 13(5), 877; https://doi.org/10.3390/v13050877
Received: 30 March 2021 / Revised: 27 April 2021 / Accepted: 7 May 2021 / Published: 11 May 2021
(This article belongs to the Special Issue Epstein Barr Virus)
Human oncogenic viruses account for at least 12% of total cancer cases worldwide. Epstein–Barr virus (EBV) is the first identified human oncogenic virus and it alone causes ~200,000 cancer cases and ~1.8% of total cancer-related death annually. Over the past 40 years, increasing lines of evidence have supported a causal link between EBV infection and a subgroup of lung cancers (LCs). In this article, we review the current understanding of the EBV-LC association and the etiological role of EBV in lung carcinogenesis. We also discuss the clinical impact of the knowledge gained from previous research, challenges, and future directions in this field. Given the high clinical relevance of EBV-LC association, there is an urgent need for further investigation on this topic. View Full-Text
Keywords: non-small cell lung cancer; NSCLC; small cell lung cancer; SCLC; Epstein–Barr virus; EBV; next-generation sequencing; NGS non-small cell lung cancer; NSCLC; small cell lung cancer; SCLC; Epstein–Barr virus; EBV; next-generation sequencing; NGS
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MDPI and ACS Style

Becnel, D.; Abdelghani, R.; Nanbo, A.; Avilala, J.; Kahn, J.; Li, L.; Lin, Z. Pathogenic Role of Epstein–Barr Virus in Lung Cancers. Viruses 2021, 13, 877. https://doi.org/10.3390/v13050877

AMA Style

Becnel D, Abdelghani R, Nanbo A, Avilala J, Kahn J, Li L, Lin Z. Pathogenic Role of Epstein–Barr Virus in Lung Cancers. Viruses. 2021; 13(5):877. https://doi.org/10.3390/v13050877

Chicago/Turabian Style

Becnel, David, Ramsy Abdelghani, Asuka Nanbo, Janardhan Avilala, Jacob Kahn, Li Li, and Zhen Lin. 2021. "Pathogenic Role of Epstein–Barr Virus in Lung Cancers" Viruses 13, no. 5: 877. https://doi.org/10.3390/v13050877

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