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Review

Influenza Virus RNA Synthesis and the Innate Immune Response

Division of Virology, Department of Pathology, University of Cambridge, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK
*
Author to whom correspondence should be addressed.
Present address: University of Heidelberg, 69120 Heidelberg, Germany.
Present address: Lewis Thomas Laboratory, Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Academic Editors: Núria Verdaguer and Diego Sebastian Ferrero
Viruses 2021, 13(5), 780; https://doi.org/10.3390/v13050780
Received: 10 April 2021 / Revised: 25 April 2021 / Accepted: 25 April 2021 / Published: 28 April 2021
(This article belongs to the Special Issue Viral Replication Complexes)
Infection with influenza A and B viruses results in a mild to severe respiratory tract infection. It is widely accepted that many factors affect the severity of influenza disease, including viral replication, host adaptation, innate immune signalling, pre-existing immunity, and secondary infections. In this review, we will focus on the interplay between influenza virus RNA synthesis and the detection of influenza virus RNA by our innate immune system. Specifically, we will discuss the generation of various RNA species, host pathogen receptors, and host shut-off. In addition, we will also address outstanding questions that currently limit our knowledge of influenza virus replication and host adaption. Understanding the molecular mechanisms underlying these factors is essential for assessing the pandemic potential of future influenza virus outbreaks. View Full-Text
Keywords: influenza A virus; RNA polymerase; RIG-I; mini viral RNA; defective interfering RNA; MAVS; interferon influenza A virus; RNA polymerase; RIG-I; mini viral RNA; defective interfering RNA; MAVS; interferon
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MDPI and ACS Style

Weis, S.; te Velthuis, A.J.W. Influenza Virus RNA Synthesis and the Innate Immune Response. Viruses 2021, 13, 780. https://doi.org/10.3390/v13050780

AMA Style

Weis S, te Velthuis AJW. Influenza Virus RNA Synthesis and the Innate Immune Response. Viruses. 2021; 13(5):780. https://doi.org/10.3390/v13050780

Chicago/Turabian Style

Weis, Sabrina, and Aartjan J. W. te Velthuis. 2021. "Influenza Virus RNA Synthesis and the Innate Immune Response" Viruses 13, no. 5: 780. https://doi.org/10.3390/v13050780

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