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Review

Degradation-Independent Inhibition of APOBEC3G by the HIV-1 Vif Protein

1
CNRS, Architecture et Réactivité de l’ARN, UPR 9002, IBMC-2 Allée Konrad Roentgen, Université de Strasbourg, F-67000 Strasbourg, France
2
Sorbonne Paris Cité, INSERM U1016, CNRS UMR8104, Institut Cochin-27 rue du Faubourg Saint-Jacques, Université Paris Descartes, F-75014 Paris, France
*
Author to whom correspondence should be addressed.
Academic Editor: Linda Chelico
Viruses 2021, 13(4), 617; https://doi.org/10.3390/v13040617
Received: 4 March 2021 / Revised: 30 March 2021 / Accepted: 1 April 2021 / Published: 3 April 2021
(This article belongs to the Special Issue APOBECs and Virus Restriction)
The ubiquitin–proteasome system plays an important role in the cell under normal physiological conditions but also during viral infections. Indeed, many auxiliary proteins from the (HIV-1) divert this system to its own advantage, notably to induce the degradation of cellular restriction factors. For instance, the HIV-1 viral infectivity factor (Vif) has been shown to specifically counteract several cellular deaminases belonging to the apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (APOBEC3 or A3) family (A3A to A3H) by recruiting an E3-ubiquitin ligase complex and inducing their polyubiquitination and degradation through the proteasome. Although this pathway has been extensively characterized so far, Vif has also been shown to impede A3s through degradation-independent processes, but research on this matter remains limited. In this review, we describe our current knowledge regarding the degradation-independent inhibition of A3s, and A3G in particular, by the HIV-1 Vif protein, the molecular mechanisms involved, and highlight important properties of this small viral protein. View Full-Text
Keywords: HIV; Vif; APOBEC3G; ubiquitin; proteasome; translation; encapsidation; deamination; RNP granules HIV; Vif; APOBEC3G; ubiquitin; proteasome; translation; encapsidation; deamination; RNP granules
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MDPI and ACS Style

Stupfler, B.; Verriez, C.; Gallois-Montbrun, S.; Marquet, R.; Paillart, J.-C. Degradation-Independent Inhibition of APOBEC3G by the HIV-1 Vif Protein. Viruses 2021, 13, 617. https://doi.org/10.3390/v13040617

AMA Style

Stupfler B, Verriez C, Gallois-Montbrun S, Marquet R, Paillart J-C. Degradation-Independent Inhibition of APOBEC3G by the HIV-1 Vif Protein. Viruses. 2021; 13(4):617. https://doi.org/10.3390/v13040617

Chicago/Turabian Style

Stupfler, Benjamin, Cédric Verriez, Sarah Gallois-Montbrun, Roland Marquet, and Jean-Christophe Paillart. 2021. "Degradation-Independent Inhibition of APOBEC3G by the HIV-1 Vif Protein" Viruses 13, no. 4: 617. https://doi.org/10.3390/v13040617

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