Phage phiKZ—The First of Giants
1
I.I. Mechnikov Research Institute of Vaccines & Sera, 105064 Moscow, Russia
2
Department of Clinical Immunology and Allergy, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation, 119146 Moscow, Russia
3
Department of Infectious Diseases, Belarusian State Medical University, 220116 Minsk, Belarus
4
Faculty of Preventive Medicine, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation, 119146 Moscow, Russia
*
Author to whom correspondence should be addressed.
Academic Editors: Julie Thomas and Lindsay Black
Viruses 2021, 13(2), 149; https://doi.org/10.3390/v13020149
Received: 1 December 2020
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Revised: 15 January 2021
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Accepted: 18 January 2021
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Published: 20 January 2021
(This article belongs to the Special Issue Giant or Jumbo Phages)
The paper covers the history of the discovery and description of phiKZ, the first known giant bacteriophage active on Pseudomonas aeruginosa. It also describes its unique features, especially the characteristic manner of DNA packing in the head around a cylinder-shaped structure (“inner body”), which probably governs an ordered and tight packaging of the phage genome. Important properties of phiKZ-like phages include a wide range of lytic activity and the blue opalescence of their negative colonies, and provide a background for the search and discovery of new P. aeruginosa giant phages. The importance of the phiKZ species and of other giant phage species in practical phage therapy is noted given their broad use in commercial phage preparations.
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Keywords:
giant phages; phage phiKZ; phage particles structure; inner body; Pseudomonas; pseudolysogeny; phage therapy
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MDPI and ACS Style
Krylov, V.; Bourkaltseva, M.; Pleteneva, E.; Shaburova, O.; Krylov, S.; Karaulov, A.; Zhavoronok, S.; Svitich, O.; Zverev, V. Phage phiKZ—The First of Giants. Viruses 2021, 13, 149. https://doi.org/10.3390/v13020149
AMA Style
Krylov V, Bourkaltseva M, Pleteneva E, Shaburova O, Krylov S, Karaulov A, Zhavoronok S, Svitich O, Zverev V. Phage phiKZ—The First of Giants. Viruses. 2021; 13(2):149. https://doi.org/10.3390/v13020149
Chicago/Turabian StyleKrylov, Victor, Maria Bourkaltseva, Elena Pleteneva, Olga Shaburova, Sergey Krylov, Alexander Karaulov, Sergey Zhavoronok, Oxana Svitich, and Vitaly Zverev. 2021. "Phage phiKZ—The First of Giants" Viruses 13, no. 2: 149. https://doi.org/10.3390/v13020149
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