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Review

Human Papillomaviruses-Associated Cancers: An Update of Current Knowledge

Division of Molecular Medicine, Ruđer Bošković Institute, Bijenička Cesta 54, 10000 Zagreb, Croatia
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Academic Editors: Stipan Jonjić, Dubravko Forčić and Andreja Ambriović-Ristov
Viruses 2021, 13(11), 2234; https://doi.org/10.3390/v13112234
Received: 16 September 2021 / Revised: 26 October 2021 / Accepted: 29 October 2021 / Published: 6 November 2021
(This article belongs to the Special Issue State-of-the-Art Virology Research in Croatia)
Human papillomaviruses (HPVs), which are small, double-stranded, circular DNA viruses infecting human epithelial cells, are associated with various benign and malignant lesions of mucosa and skin. Intensive research on the oncogenic potential of HPVs started in the 1970s and spread across Europe, including Croatia, and worldwide. Nowadays, the causative role of a subset of oncogenic or high-risk (HR) HPV types, led by HPV-16 and HPV-18, of different anogenital and head and neck cancers is well accepted. Two major viral oncoproteins, E6 and E7, are directly involved in the development of HPV-related malignancies by targeting synergistically various cellular pathways involved in the regulation of cell cycle control, apoptosis, and cell polarity control networks as well as host immune response. This review is aimed at describing the key elements in HPV-related carcinogenesis and the advances in cancer prevention with reference to past and on-going research in Croatia. View Full-Text
Keywords: human papillomaviruses (HPV); oncoproteins; proteomics; epigenetics; biomarkers; cancer; therapeutics; immunology human papillomaviruses (HPV); oncoproteins; proteomics; epigenetics; biomarkers; cancer; therapeutics; immunology
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MDPI and ACS Style

Pešut, E.; Đukić, A.; Lulić, L.; Skelin, J.; Šimić, I.; Milutin Gašperov, N.; Tomaić, V.; Sabol, I.; Grce, M. Human Papillomaviruses-Associated Cancers: An Update of Current Knowledge. Viruses 2021, 13, 2234. https://doi.org/10.3390/v13112234

AMA Style

Pešut E, Đukić A, Lulić L, Skelin J, Šimić I, Milutin Gašperov N, Tomaić V, Sabol I, Grce M. Human Papillomaviruses-Associated Cancers: An Update of Current Knowledge. Viruses. 2021; 13(11):2234. https://doi.org/10.3390/v13112234

Chicago/Turabian Style

Pešut, Ena, Anamaria Đukić, Lucija Lulić, Josipa Skelin, Ivana Šimić, Nina Milutin Gašperov, Vjekoslav Tomaić, Ivan Sabol, and Magdalena Grce. 2021. "Human Papillomaviruses-Associated Cancers: An Update of Current Knowledge" Viruses 13, no. 11: 2234. https://doi.org/10.3390/v13112234

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