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Therapy Implications of Hepatitis C Virus Genetic Diversity

Miguel Angel Martínez, IrsiCaixa, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Spain
Author to whom correspondence should be addressed.
Academic Editor: Brett Lindenbach
Viruses 2021, 13(1), 41;
Received: 26 November 2020 / Revised: 11 December 2020 / Accepted: 22 December 2020 / Published: 29 December 2020
(This article belongs to the Special Issue Diversity and Evolution of HIV and HCV)
Hepatitis C virus (HCV) is an important human pathogen with a high chronicity rate. An estimated 71 million people worldwide are living with chronic hepatitis C (CHC) infection, which carries the risk of progression to hepatic fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Similar to other RNA viruses, HCV has a high rate of genetic variability generated by its high mutation rate and the actions of evolutionary forces over time. There are two levels of HCV genetic variability: intra-host variability, characterized by the distribution of HCV mutant genomes present in an infected individual, and inter-host variability, represented by the globally circulating viruses that give rise to different HCV genotypes and subtypes. HCV genetic diversity has important implications for virus persistence, pathogenesis, immune responses, transmission, and the development of successful vaccines and antiviral strategies. Here we will discuss how HCV genetic heterogeneity impacts viral spread and therapeutic control. View Full-Text
Keywords: HCV; genetic diversity; quasispecies; therapy HCV; genetic diversity; quasispecies; therapy
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MDPI and ACS Style

Martinez, M.A.; Franco, S. Therapy Implications of Hepatitis C Virus Genetic Diversity. Viruses 2021, 13, 41.

AMA Style

Martinez MA, Franco S. Therapy Implications of Hepatitis C Virus Genetic Diversity. Viruses. 2021; 13(1):41.

Chicago/Turabian Style

Martinez, Miguel Angel, and Sandra Franco. 2021. "Therapy Implications of Hepatitis C Virus Genetic Diversity" Viruses 13, no. 1: 41.

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