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Ion Channels as Therapeutic Targets for Viral Infections: Further Discoveries and Future Perspectives

1
School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK
2
School of Biomedical Sciences, University of Leeds, Leeds LS2 9JT, UK
*
Author to whom correspondence should be addressed.
Viruses 2020, 12(8), 844; https://doi.org/10.3390/v12080844
Received: 10 July 2020 / Revised: 29 July 2020 / Accepted: 29 July 2020 / Published: 3 August 2020
(This article belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Ion channels play key roles in almost all facets of cellular physiology and have emerged as key host cell factors for a multitude of viral infections. A catalogue of ion channel-blocking drugs have been shown to possess antiviral activity, some of which are in widespread human usage for ion channel-related diseases, highlighting new potential for drug repurposing. The emergence of ion channel–virus interactions has also revealed the intriguing possibility that channelopathies may explain some commonly observed virus induced pathologies. This field is rapidly evolving and an up-to-date summary of new discoveries can inform future perspectives. We herein discuss the role of ion channels during viral lifecycles, describe the recently identified ion channel drugs that can inhibit viral infections, and highlight the potential contribution of ion channels to virus-mediated disease. View Full-Text
Keywords: virus; ion channel; virus–host interactions; channelopathies; antivirals virus; ion channel; virus–host interactions; channelopathies; antivirals
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MDPI and ACS Style

Charlton, F.W.; Pearson, H.M.; Hover, S.; Lippiat, J.D.; Fontana, J.; Barr, J.N.; Mankouri, J. Ion Channels as Therapeutic Targets for Viral Infections: Further Discoveries and Future Perspectives. Viruses 2020, 12, 844. https://doi.org/10.3390/v12080844

AMA Style

Charlton FW, Pearson HM, Hover S, Lippiat JD, Fontana J, Barr JN, Mankouri J. Ion Channels as Therapeutic Targets for Viral Infections: Further Discoveries and Future Perspectives. Viruses. 2020; 12(8):844. https://doi.org/10.3390/v12080844

Chicago/Turabian Style

Charlton, Frank W., Hayley M. Pearson, Samantha Hover, Jon D. Lippiat, Juan Fontana, John N. Barr, and Jamel Mankouri. 2020. "Ion Channels as Therapeutic Targets for Viral Infections: Further Discoveries and Future Perspectives" Viruses 12, no. 8: 844. https://doi.org/10.3390/v12080844

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